Antibiotics And shit

Question 1

compounds that inhibits DNA functioning

Answer 1

Flucytosine
Gryseofulvin
Pentamide isethinate

Question 2

compounds that change membrane permeability

Answer 2

amphotericin B and nystatin
- Zoles
terbinafines

Question 3

flucytosine

Answer 3

enters fungal cells and is deaminated to fluorouracil and reprecess pyrimidine metabolism

(not many Se)

Question 4

griseofulvin

Answer 4

inhibits fungal cell mitosis
interacts with microtubules and disrupts mitotic spindles

binds to intracellular lipids= stunting and shrinking of fungal hyphae

(affects kidneys)

Question 5

pentamidine isethionate

Answer 5

interferes with nuclear functions and metabolism by inhibition of dna synthesis

Question 6

amphotericin B and nystatin

Answer 6

deplete ergosterol and don’t allow it to be incorporated into fungal cytoplasmic membranes ( amphotericin was a pesticide and has shitty side effect s)

Question 7

all the - Zoles

Answer 7

inhibits ergosterol synthesis by preventing conversion of lanosterol to ergosterol
loss of cell membrane integriy

Question 8

terbinafine

Answer 8

toxic accumulation of squalene that deplete ergosterol in cell membrane

Question 9

protozoa drugs

Answer 9

antimony sodium gluconate
chloroquine
metronidazole
nifutimox
paromomycin 
propamidine
pyrimethamine sulfathiazied
suramin

Question 10

Trematode drugs

Answer 10

praziquantel**

Question 11

cestode drugs

Answer 11

niclosamide

Question 12

nematode drugs

Answer 12

diethyl carbamazine
Zoles
ibermectin

Question 13

arthropod drugs

Answer 13

Malathion

permethrins

Question 14

antimony sodium gluconate

Answer 14

blocks energy production in protozoan cells

(metal thats harsh)*

Question 15

chloroquine

Answer 15

inhibits hemoglobin breakdown in human RBs

iron is toxic for humans and parasites but parasite has blocking agent like in malaria

Question 16

metronidazole and diloxanide furoate

Answer 16

inhibits dna synthesis and protein formation

Question 17

nifurtimos

Answer 17

produces high levels of hydrogen peroxide* that inhibits dna synthesis and damages protozoan cell membranes

Question 18

paromomycin

Answer 18

binds to ribosomal rna causing defective polypeptides to be produced

Question 19

propamidine

Answer 19

produces mitochondiral membrane damage in protozoan cells

Question 20

pyrimethamine sulfadiazine

Answer 20

inhibit dna synthesis and disrupt mitochondria in protozoa

Question 21

suramin

Answer 21

inhibits enzyme activity and damages intracellular compounds

Question 22

praziquantel***

Answer 22

tx trematodes

increase calcium permeability producing muscle paralysis and vacuolization/ gesticulation of the worms tegument
cestode tx too

(not many se)

Question 23

niclosamide

Answer 23

tx cestode

uncouples the oxidative phosphorylation in tapeworm mitochondria

Question 24

diethyl carbamizen

Answer 24

tx nematode

damages microfilarial membranes and immobilizes nematode larvae*

Question 25

Zoles

Answer 25

tx nematode

bund to nematode tubular and inhibits cytoplasmic microtubule formation in nematode

Question 26

ivermectin

Answer 26

increases cl permeability producing paralysis of nematode

Question 27

malathion

Answer 27

tx arthropod

neurological poison stimulates nicotinic ach receptors – resulting in muscle rigitidy

Question 28

permethrins

Answer 28

neurotoxin, prolongs sodium channel activation