Antibiotics And shit Flashcards
compounds that inhibits DNA functioning
Flucytosine
Gryseofulvin
Pentamide isethinate
compounds that change membrane permeability
amphotericin B and nystatin
- Zoles
terbinafines
flucytosine
enters fungal cells and is deaminated to fluorouracil and reprecess pyrimidine metabolism
(not many Se)
griseofulvin
inhibits fungal cell mitosis
interacts with microtubules and disrupts mitotic spindles
binds to intracellular lipids= stunting and shrinking of fungal hyphae
(affects kidneys)
pentamidine isethionate
interferes with nuclear functions and metabolism by inhibition of dna synthesis
amphotericin B and nystatin
deplete ergosterol and don’t allow it to be incorporated into fungal cytoplasmic membranes ( amphotericin was a pesticide and has shitty side effect s)
all the - Zoles
inhibits ergosterol synthesis by preventing conversion of lanosterol to ergosterol
loss of cell membrane integriy
terbinafine
toxic accumulation of squalene that deplete ergosterol in cell membrane
protozoa drugs
antimony sodium gluconate chloroquine metronidazole nifutimox paromomycin propamidine pyrimethamine sulfathiazied suramin
Trematode drugs
praziquantel**
cestode drugs
niclosamide
nematode drugs
diethyl carbamazine
Zoles
ibermectin
arthropod drugs
Malathion
permethrins
antimony sodium gluconate
blocks energy production in protozoan cells
(metal thats harsh)*
chloroquine
inhibits hemoglobin breakdown in human RBs
iron is toxic for humans and parasites but parasite has blocking agent like in malaria
metronidazole and diloxanide furoate
inhibits dna synthesis and protein formation
nifurtimos
produces high levels of hydrogen peroxide* that inhibits dna synthesis and damages protozoan cell membranes
paromomycin
binds to ribosomal rna causing defective polypeptides to be produced
propamidine
produces mitochondiral membrane damage in protozoan cells
pyrimethamine sulfadiazine
inhibit dna synthesis and disrupt mitochondria in protozoa
suramin
inhibits enzyme activity and damages intracellular compounds
praziquantel***
tx trematodes
increase calcium permeability producing muscle paralysis and vacuolization/ gesticulation of the worms tegument
cestode tx too
(not many se)
niclosamide
tx cestode
uncouples the oxidative phosphorylation in tapeworm mitochondria
diethyl carbamizen
tx nematode
damages microfilarial membranes and immobilizes nematode larvae*
Zoles
tx nematode
bund to nematode tubular and inhibits cytoplasmic microtubule formation in nematode
ivermectin
increases cl permeability producing paralysis of nematode
malathion
tx arthropod
neurological poison stimulates nicotinic ach receptors – resulting in muscle rigitidy
permethrins
neurotoxin, prolongs sodium channel activation
