Antibiotics Flashcards
Penicillin spectrum
Gram +ve and anaerobes
Mode of action of penicillin
Inhibits cell wall synthesis, bactericidal
Licenced routes of penicillin
IM
Lactating cow
Oral
Amoxicillin spectrum
Broad spectrum
Better gram -ve than +ve
Amoxicillin mode of action
Inhibits cell wall synthesis, bactericidal
Licensed routes of amoxicillin
IM
Dry cow preparations
Oral
Tetracyline spectrum
Broad spectrum, gram +ve and -ve, some anaerobes
Active against Mycoplasma and Chlamydia
Which licensed farm animal antibiotics are active against Mycoplasma?
Tetracyclines and aminoglycosides
Which licenced farm animal antibiotic is effective against Chlamydia?
Tetracyclines
Action of tetracyclines
Inhibits protein synthesis, bacteriostatic
Licensed routes of tetracylines
IV
IM
Oral
Intra-uterina
Aerosol spray
Antibiotics that can be delivered IV (important if cow is sick)
Tetracylines
Trimethoprim sulphonamides
Spectrum of trimethoprim sulphonamides
Broad spectrum, some anaerobes
Mode of action of trimethoprim sulphonamides
Inhibits folate pathway of bacteria, bacteriostatic
Licensed routes of trimethoprim sulphonamides
IV
IM
Subcutaneous
Oral
Aminoglycoside/spectinomycin spectrum
Broad spectrum, gram +ve and some gram -ve
Little anaerobic activity
Mycoplasma
Aminoglycoside/spectinomycin mode of action
Inhibits protein synthesis, bactericidal
Licensed route of aminoglycoside/spectinomycin in farm animals
Oral
Which farm animal antibiotics can penetrate abscesses?
Penicillins
Amoxicillin
Which farm animal antibiotics can penetrate soft tissues?
Penicillins
Amoxicillin
Where do tetracyclines have a good distribution?
Urinary tract, respiratory tract and intestines
What can inactivate trimethoprim sulphonamides?
Pus/necrotic tissue
Antibiotics with good distribution in GIT
Trimethropin sulphonamides
Aminoglycosides/spectinomycin (stays in GIT after oral administration)
