Antianemics, hematopoietic, coagulants and thrombolytics

Question 1

What are the two clotting pathways through fibrin mechanisms

Answer 1

Intrinsic and extrinsic

Question 2

The intrinsic clotting pathway is sensitive to what as an anticlotting agent?

Answer 2

Heparin

Question 3

What are side effects of heparin?

Answer 3

Hemorrhage, allergic reactions, osteoporosis and bone fractures

Question 4

Intrinsic clotting pathways contact which factors?

Answer 4

XIa to Xa

Question 5

What is the normal PTT time for intrinsic pathways?

Answer 5

25-35 seconds

Question 6

What is PTT?

Answer 6

Partial thromboplastin time (Intrinsic)

Question 7

What anti-clotting agent is typically used in hospitals?

Answer 7

Heparin

Question 8

Extrinsic factors pathway works through what factors?

Answer 8

VIIa-Xa

Question 9

Extrinsic pathways are measured how?

Answer 9

PT (Prothrombin time)/INR (international normalized ratio)

Question 10

What is the normal PT in seconds and INR for an extrinsic pathway?

Answer 10

Normal PT is 11-13.5 seconds

Normal INR is 0.8-1.1

Question 11

What are extrinsic pathways sensitive to?

Answer 11

warfarin (Coumadin)

Question 12

When is oral warfarin prescribed?

Answer 12

Out patients

Question 13

What are the common side effects of warfarin?

Answer 13

hemorrhage, numbness, pain, headache, dizziness

Question 14

What is an alternative drug for warfarin with fewer side effects?

Answer 14

Dabigatran

Question 15

Alternative drugs are (more/less) popular than warfarin or heparin.

Answer 15

More

Question 16

Normal INR for the extrinsic pathway is what

Answer 16

.8 to 1.1