Anti-virals

Question 1

Name 6 steps in the Influenza life cycle

Answer 1

1) Binding to cell via haemagglutinin and sialic acid. 2) Endocytosis 3)ATP/H+ pump reducing endosome pH, causing fusion of the viral and endosome membranes. 4) Viral M2 channels decrease viral pH, causing uncoating and viral RNA release. 5) Virion/ protein synthesis. 6) Virion budding off via neuraminidase action.

Question 2

Name some M2 Ion Channel Blockers

Answer 2

Rimantidine and Amantidine

Question 3

What type of Influenza viruses are M2 ion channel blockers effective?

Answer 3

Only Group A

Question 4

Name some M2 ion channel blocker ADRs

Answer 4

Dizziness, hypotension, confusion and insomnia.

Question 5

Name some neuraminidase inhibitors and there routes of administration.

Answer 5

Zanamivir (inhaled) and Oseltamivir (oral).

Question 6

What are neuraminidase inhibitors analogues of?

Answer 6

Siliac acid

Question 7

What are some neuraminidase inhibitor ADRs?

Answer 7

Respiratory depression, bronchospasm and epistaxis.

Question 8

What condition must be met for neuraminidase inhibitors to be effective in symptom reduction?

Answer 8

Administered within 48 hours of symptom onset.