Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Anti-arrhythmics > Flashcards

Anti-arrhythmics Flashcards

1
Q

What are class 1 anti-arrhythmics and what phase do they act on?

A

Sodium channel blockers, acting on phase 0.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are class 2 anti-arrhythmics and what phase do they act on?

A

Beta-adrenoreceptor blockers, acting on phase 4.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are class 3 anti-arrhythmics and what phase do they act on?

A

Potassium channel blcokers, acting on phase 3.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are class 4 anti-arrhythmics and what phase do they act on?

A

Calcium channel blockers, acting on phase 2.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the sub-classes of phase 1 and what differentiates them?

A

Class 1a, increases action potential duration, class Ib, decreases action potential duration, and class 1c, which doesn’t change action potential duration.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Give an example of an oral Ic anti-arrhythmic

A

Flecanide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Give an example of an intravenous 1b anti-arrhythmic

A

Lidocaine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are contraindications in class 1 anti-arrhythmics?

A

Heart failure, AV block, and previous MI.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are common ADRs of flecanide?

A

Dizziness, arrythmia, and visual disturbance.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are common ADRs of lidocaine?

A

Nystagmus, hypotension, bradycardia and seizure.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What effect do class III anti-arrythmics have on the heart conduction?

A

Increase the absolute refractory period and action potential duration.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Give two examples of class III anti-arythmics

A

Amiodarone and Sotalol (at high dose, acts as class II at low dose).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is a common ADR of class III anti-arrythmics?

A

Arrythmia (specifically torsades de pointes, reversible with magnesium)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is a contraindication for class III anti-arrythmics?

A

AV block.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Why can amiodarone cause DDIs?

A

It is a CYP450 inhibitor.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What ADRs can amiodarone specifically cause?

A

Interstitial lung disease, hypothyroidism and hyperthyroidism.

17
Q

What effect do class IV anti-arrythmics have on the heart?

A

Increased refractory period, decreased pacemaker depolarisation, decreased inotropy and chronotropy.

18
Q

What can class IV anti-arrythmics be used for?

A

Supraventricular arrythmias, angina and hypertension.

19
Q

What are some contraindications for class IV anti-arrythmic use?

A

Heart failure, bradycardia and AV block.

20
Q

What are some ADRs for class IV anti-arryhtmic use?

A

Hypotension, bradycardia, heart failure and heart block.

21
Q

Name 2 class IV anti-arrythmics

A

Verapamil and Dilteazem

22
Q

What is adenosine, what can it be used to diagnose, and why is it safe to do so?

A

It is an AV node blocker, that can be used to diagnose supraventricular tachycardia, and is safe to use as it has a half-life of only a few seconds.

Pharmacology (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions