Anti-Pyschotics (2) Flashcards
What affect does Closapine have on
D4 and 5-HT2
D2
Muscarnic
Blocks D4 and 5‐HT2 receptors
• Little effect on D2
• Muscarinic antagonist
Clozapine (atyipcal) has what effect on + and - symptoms
Improves + symptoms in pts not helped by others
Improves negative symptoms
What are 2 big sideffects of Clozapine
Lowers seizure threshold
can cause fatal agranulocytosis
Effect of Olanzapine on
5-HT2
D1 and D2
D4
Potent 5-HT antagonist
D1, D2 ANTagonist, some D4
What is the side effect profile of olanzapine
few EPS and less seizure concern then Clozapine
Weight gain and diabetes adn possible abuse (snorting)
Combined D2 and 5HT-2 antagonist with greater reduction in negative sypmtoms and less EPS
Risperidone
has less seizure and antimuscarninic acitiviy then Clozapine
Risperidone
What is the active metabolite of Risperidone, how is it administered
Paliperidone
given as injection
Drug with simular effects on schizophrenia as risperidone and olanzapine but with a shorter half life
Quetiapine
What antipyschotic is approved for augmentation in depression
Quetiapine
5-HT2 and D2 antagonist
may ahve 5-HT1a agonist activity, no weight gain
Ziprasidone
A partial D2 agonist and 5HT2 antagonist, also approved for adjunct to tx depression
Aripiprazole
Uses of Antipsychotics
Acute episodes Chronic schizophrenia Manic episodes Schizoaffective Augment depression Tourettes Antiemesis
What drugs do we tx schizoaffective disorder with?
Paliperidone
What antipyschotics can we use to augment depression
Aripiprizole, olanzapine, quetiapine