Anti-Platelets

Question 1

Actions of aspirin

Answer 1

Stops prostaglandin synthesis

Question 2

Uses of aspirin

Answer 2

Prevention of MI and for thrombolysis

Question 3

Risks of aspirin

Answer 3

GI bleed

Question 4

Action of clopidogrel

Answer 4

Non-competitive irreversible antagonists of platelet ADP receptors, reducing expression of gpIIa/IIIA reducing aggregation.

Question 5

Where is clopidogrel activated

Answer 5

Liver

Question 6

Uses of clopidogrel

Answer 6

Prevention of MI and stroke, patients intolerant to low-dose aspirin, post-MI or intracoronary stent +/- aspirin.

Question 7

Risk of clopidogrel

Answer 7

Neutropenia and GI bleed

Question 8

Eg of glycoprotein IIb/IIa antagonists

Answer 8

Abciximab and Tirofiban

Question 9

Uses of Abciximab and Tirofiban

Answer 9

Angioplasty procedures to prevent thrombolysis with heparin and aspirin

Question 10

Side effects of Abciximab and Tirofiban

Answer 10

Haemorrhage

Question 11

Action of Dipyridamole

Answer 11

Inhibits platelet phosphodiesterase, increases cAMP and reduces aggregation

Question 12

Action of Epoprostelol

Answer 12

Synthetic PG12 which mimics prostacyclines anti-aggregates effect

Question 13

Examples of plasminogen activators

Answer 13

Streptokinase, urokinase and recombinant plasminogen activators alteplase and reteplase

Question 14

When are plasminogen activators given

Answer 14

Given IV or IC <12 hours post MI