Anti-infective drugs Flashcards
drugs that are designed to act selectively on foreign organisms that have invaded and infected the body
ANTI-INFECTIVE AGENTS
2 Spectrum of anti-bacterial agent
- Narrow spectrum anti-infectives
- Broad-spectrum anti-infectives
These affect only a few bacterial types
NARROW SPECTRUM
These affect many bacteria
BROAD-SPECTRUM
Examples of narrow-spectrum
EARLY PENICILLIN DRUGS
Example of broad spectrum
MEROPENEM
Antibiotics that can aggressively cause bacterial death are called ___
BACTERICIDAL
Anti-Bacterial agents that interfere with the ability of the cell to reproduce/replicate without killing them are called
BACTERIOSTATIC
Broad Spectrum Penicillins (aminopenicillin)
Amoxicillin
Ampicillin
Bacampicillin
Narrow spectrum penicillin
PENICILLIN G
PENICILLIN V
Penicillinase-resistant Penicillin (anti-staphylococcal penicillin)
Cloxacillin
Nafcillin
Methicillin
Dicloxacillin
Oxacillin
Extended-Spectrum penicillins (Anti-pseudomonal penicillins)
Carbenicillin
Mezlocillin
Piperacillin
Ticacillin
Beta-lactamase inhibitors
Clavulanic acid
Sulbactam
Tazobactam
T/F:
Penicillin and penicillinase-resistant penicillins produce BACTERICIDAL effects by interfering with the ability of susceptible bacteria from biosynthesizing the framework of the cell wall.
TRUE
These are indicated for the treatment of streptococcal infections.
PENICILLINS
Describe each generations of Cephalosporins (4)
1ST GEN: same gram-positive organisms affected by penicillin
2ND GEN: Haemophilus influenza, Entreobacter aerogenes and Nesseria sp. Less effective against gram (+) bacteria
3RD GEN: relatively weak against gram-positive bacteria but more potent against gram-negative bacteria, to include Serratia marcescens.
4TH: resistant gram-negative bacteria
This gen of cephalosporin is are largely effective against the same gram-positive organisms affected by penicillin.
1ST GEN
This gen of cephalosporin are effective against those strains as well as Haemophilus influenza, Entreobacter aerogenes and Nesseria sp. These drugs are less effective against gram positive bacteria
2ND GEN
This gen of cephalosporin
This gen of cephalosporin are relatively weak against gram-positive bacteria but more potent against gram-negative bacteria, to include Serratia marcescens.
3RD GEN
This gen of cephalosporin are developed to fight against the resistant gram-negative bacteria. The first drug is cefepime
4TH GEN
