Antacids/antiemetics/antinausea Flashcards
How do proton pump inhibitors work?
irreversible inhibition of the H+, K+ and ATPase proton pump
Take with food
(this drug blocks the pump)
Adverse/Complications of proton pump inhibitors
- long term or high doses may increase the risk of fractures
- Risk of C. diff because the stomach acid can’t kill bacteria
- they may decrease calcium absorption
Histamine-2 receptor blockers
decrease HCL acid
reduce symptoms and promote esophageal healing
no side effects
How do Histamine-2 blockers work?
Blocks H2 receptors on parietal cells (parietal cells produce gastric acid)
take this drug with food
Sucralfate
acid protective
pro-kinetic drugs
promote gastric emptying
metoclopramide
pro-kinetic drug for GERD
4 categories of Antacids
- Aluminum hydroxide
- Magnesium hydroxide
- Calcium carbonate
- Sodium bicarbonate
Which OTC should be used with caution in a patient with osteoporosis?
omeprazole
PUD Drug therapy
PPIs H2 R blockers antibiotics antacids anticholinergics cyto-protective therapy
Why use Antibiotic therapy for PUD
eradicates H.pylori
combination therapy with a proton-pump inhibitor
Clarithromycin
antibiotics
suppressed growth of H.pylori by inhibiting protein synthesis
Aluminum hydroxide antacids
relatively low acid neutralizing long duration used in combination with magnesium or hydroxide has tons of sodium causes constipation interacts with antibiotics
Magnesium hydroxide antacids
rapid acting an antacid of choice cause diarrhea combination with aluminum used as a laxative use with caution in patients with renal failure
Calcium carbonate antacids
rapid acting High acid neutralizing long duration causes constipation belching and flatulence
