ANS part 2 Flashcards
what type of receptors re found in the CNS?
nicotinic and muscarinic
what type of receptors are found in the vascular smooth muscle (ENDOTHELIUM)?
muscarinic
what are the main locations of M1 muscarinic receptors?
autonomic ganglia, glands: gastric, salivary, lacrimal - GASTRIC SECRETION
what are the main locations and functions of M2 muscarinic receptors?
mainly on the heart, effect cardiac inhibition
what are the main locations and functions of M3 muscarinic receptors?
exocrine glands (gastric, salivary); smooth muscle (GI tract, airway, bladder) endothelium
GI SMOOTH MUSCLE ACTIVITY
VASODILATION
what type of drugs are pilocarpine and bethanechol?
non-selective muscarinic AGONISTS
what are the clinical uses of pilocarpine?
pupil contstriction (therefore treats glaucoma and intraocular pressure)
what are the clinical uses of bethanechol?
used to counteract bladder and GI hypotonia
which drug which acts on the muscarinic receptor, is a non-selective ANTAGONIST; is well absorbed orally and has CNS effects?
ATROPINE
clinical uses - adjunct for anaesthesia, anti cholinesterase poisoning, bradycardia, cardiac arrest
which drug is used for mydriasis?
Tropicamide (pupillary dilation)
which drug is similar to atropine except it doesn’t have any effects on the CNS?
glycopyronium
which drug is used to treat hyper salivation and motion sickness?
hyoscine hydrobromide
which drug is used to treat GI spasms?
hyoscine butylbromide
which drug is used in the treatment of COPD?
ipratropium
