Anesthesia Flashcards
An internal pressure regulator on the anesthesia machine reduces the carrier gas pressure from that in the tank or wall outlet to _____ pounds per square inch (PSI).
50
Respiratory acidosis occurs when hypoventilation causes ________ or an __________ in the blood PaCO2. The compensatory response to this condition is increased renal excretion of ______ which results in ___________ extracellular HCO3−.
hypercapnia, or an increase
H+
increased
What is a possible cause of transudative pericardial effusion?
- Congestive heart failure
- Peritoneopericardial diaphragmatic hernia
- Hypoalbuminemia
- Increased vascular permeability
Other causes include .
Define exudative pericardial effusion based on total protein and total nucleated cell count.
Total protein >2.5 g/dL; total nucleated cell count >5000 cells/µL
Exudate results from infectious or noninfectious pericarditis.
What are some infectious agents that can cause exudative pericardial effusion?
Bacterial, fungal, or viral
Examples include feline infectious peritonitis and feline cardiomyopathy.
Which fungal agent is noted to cause pericarditis in dogs in the southwestern United States?
Coccidioides immitis
Fungal pericarditis is unusual, but this agent is an exception.
What is a suspected cause of bacterial pericardial effusion in dogs?
Grass awn migration
List some causes of hemorrhagic pericardial effusion.
- Trauma
- Neoplasia
- Anticoagulant intoxication
- Rupture of the left atrium secondary to mitral valve disease
These conditions can lead to bleeding into the pericardial space.
What is the formula for Respiratory Minute Volume (MV)?
Respiratory Rate x Tidal Volume
What is the estimated tidal volume in mL/kg?
15 mL/kg
What is the recommended gas flow rate for a nonrebreathing system in relation to Minute Volume (MV)?
At least 3 times MV
What are possible complications of epidural injections?
- Injection of local anesthetic into the vertebral sinuses
- Respiratory depression and paralysis and dogs and cats caused by drug overdose
- Temperature may fall in small animals because they are unable to shiver
These complications highlight the risks associated with epidural anesthesia.
What respiratory issues can occur in dogs and cats due to drug overdose?
Respiratory depression and paralysis
This condition is serious and can lead to inadequate breathing.
The drug must migrate to _______ to produce complete respiratory paralysis from blockade of the phrenic nerves.
approximately C5 or C7
Phrenic Nerve C5, C6, C7
What physiological change may occur in small animals due to inability to shiver?
Temperature may fall
This can lead to hypothermia in susceptible animals.
What nerve blockade is responsible for respiratory paralysis?
Phrenic nerves
The phrenic nerves are crucial for diaphragm function and breathing.
Injection of local anesthetic into the vertebral sinuses can lead to:
- Vomiting
- Tremors
- Decreased blood pressure caused by peripheral vasodilation
- Convulsions
- Paralysis
- Lack of intended effect
What increases with ventilation perfusion mismatch (V/Q)?
Increased ventilation and decreased perfusion
V/Q mismatch can lead to various respiratory issues and is a critical concept in understanding pulmonary function.
What is the function of one-way valves in an anesthesia machine?
Prevent immediate rebreathing of exhaled gas
One-way valves ensure that exhaled gases do not return to the patient, thus maintaining the integrity of the anesthetic circuit.
What surface does a reverse-cutting needle have the cutting surface on?
Convex surface
Reverse-cutting needles create a unique triangular hole.
What shape does the hole created by a reverse-cutting needle have?
Triangular hole
The triangular hole has a flat edge.
The flat edge of the hole created by a reverse-cutting needle is _______ to the incision.
Parallel
This design helps in reducing tissue trauma.
What is the tidal volume (TV) setting range for mechanical ventilators?
10-20 mL/kg
Tidal volume refers to the amount of air delivered to the lungs with each breath.
Recommended Chlorhex duration ____ minutes.
vs.
Alcohol-based hand rub solutions have similar efficacy w/in ____ minutes. Gold standard!
3-5 minutes
1.5-2 minutes
What is the recommended respiratory rate (RR) for mechanical ventilators?
8-12 breaths per minute
This rate helps ensure adequate ventilation without causing respiratory alkalosis.
What is the recommended respiratory rate (RR) for mechanical ventilators?
8-12 breaths per minute
This rate helps ensure adequate ventilation without causing respiratory alkalosis.
What is the peak inspiratory pressure (PIP) range for mechanical ventilators?
10-20 cm H2O
PIP is the maximum pressure applied to the airways during inhalation.
What is the typical inspiratory/expiratory (I/E) ratio for mechanical ventilation?
1:2
This ratio helps maintain optimal gas exchange during mechanical ventilation.
What does CO2 react with to form carbonic acid on the surface of granules?
Soda Lime
Water
This reaction is crucial for the function of Soda Lime in absorbing CO2.
When should Soda Lime be changed?
Soda Lime
Whenever rebreathing of CO2 by patient is observed on capnograph
This indicates that the granules are no longer effectively removing CO2.
What happens to Soda Lime granules at higher fresh gas flow?
Soda Lime
Granules may lose water to evaporation
This can make them less effective for CO2 removal.
Fill in the blank: CO2 reacts with water to form _______ on the surface of granules.
Soda Lime
[carbonic acid]
True or False: Minimal regeneration of Soda Lime occurs over time.
Soda Lime
True
This suggests that Soda Lime has a limited lifespan and needs to be monitored.
What is the consequence of using Soda Lime granules that have lost water?
Soda Lime
They become less effective for CO2 removal
Maintaining adequate hydration of the granules is essential for their function.
What is the relationship between fresh gas flow and the effectiveness of Soda Lime?
Soda Lime
Higher fresh gas flow can lead to reduced effectiveness due to evaporation of water
This highlights the importance of managing gas flow rates in anesthesia.
What does a rebreathing system allow?
Rebreathing System
Rebreathing of exhaled gases minus CO2
This system recycles gases that have been exhaled, excluding carbon dioxide.
What does the amount of rebreathing in a rebreathing system depend on?
Rebreathing System
Fresh gas flow rate
The rate at which fresh gas is supplied affects how much exhaled gas is rebreathed.
What do nonrebreathing systems rely on?
Nonrebreathing System
Relatively HIGH fresh gas flow rates to remove CO2
Nonrebreathing systems require higher flow rates to ensure that carbon dioxide is effectively removed from the gas mixture.
Are Touhy needles:
* uninsulated or insulated
* curved or straight at the tip
* sharp or not sharp
- Uninsulated or insulated
- Curved at the distal tip
- Not as sharp
Touhy needles are used for?
epidural or perineural catheters
Name the Pain Nerves
A-alpha - proprioception
A-beta - touch
A-delta - pain (mechanical and thermal)
C - pain (mechanical, thermal, chemical)
Unmyelinated
How/where to block thoracic limb cat?
Brachial plexus C6-T1 VENTRAL BRANCHES
What are the ventral branches of the brachial plexus?
Suprascapular, subscapular, axillary, musculocutaneous, radial, median, ulnar nerves
The specific spinal levels for each nerve are: Suprascapular + subscapular (C6-7), axillary + musculocutaneous (C6-8), radial (C6-T2), median (C7-T1), ulnar (C8-T2)
What is Regional or Nerve Block Anesthesia?
Injection of LRA (local regonal anesthesia) adjacent to a peripheral nerve to temporarily block conduction.
This results in the temporary interruption of sensory afferent and/or motor efferent activity.
What are the major landmarks for brachial plexus block?
Scapulohumeral joint, acromion, greater tubercle, jugular vein
These landmarks are critical for proper needle placement during the procedure.
Where is the puncture site located for brachial plexus block?
Cranial to the acromion and medial to the subscapularis muscle
What is the direction of needle advancement during brachial plexus block?
Medial to the scapula in a caudal direction
This technique helps ensure proper placement of the anesthetic agent.
Fill in the blank: The spinal levels for the axillary and musculocutaneous nerves are _______.
C6-8
True or False: The radial nerve spans from C6 to T2.
True
The phases of end-tidal capnograph waveform?
Phase 1: Inspiratory Baseline
Phase 2 : Rise (expiratory upstroke)
Phase 3 : Alveolar Plateau
Phase 4 : inspiratory downstroke
What happens to the capnograph waveform with hypoventilation?
Elevated plateau
Increase in horizontal portion, which is elevation of plateau (phase 3)
Wit
What happens to the capnograph waveform with rebreathing CO2?
Elevated baseline (phase 1)
What happens to the capnograph waveform with hyperventilation?
Decrease plateau
What is the difference from PCO2 vs PaCO2?
PCO2 refers to the partial pressure of carbon dioxide, while PaCO2 specifically indicates the partial pressure of carbon dioxide in arterial blood
What happens with drugs in a hypoproteinemic patient?
- Increased amount of circulating free drug
- Propofol: much smaller dose needed for effect
- Opioids and benzos need much smaller dose
- Inhalants are not affected
What type of neuromuscular blocker is Atracurium?
Nondepolarizing Neuromuscular blocker
Blocks acetylcholine (Ach) at the neuromuscular junction (NMJ)
What are the cardiovascular effects of Atracurium at normal doses?
Minimal cardiovascular effects
Large doses can stimulate histamine release
Is Atracurium safe for patients with hepatic and renal diseases?
Yes
It is indicated for use in patients with these conditions
Does Atracurium provide analgesia or sedation?
No
It does not provide pain relief or sedation
What is the onset time for Atracurium when administered intravenously?
3-5 minutes
It takes this time to achieve initial effects
How long does the central eye position last after Atracurium administration?
20 to 30 minutes
This duration is important for surgical procedures
Is reversal of Atracurium blockade usually necessary?
What drug is used to reverse?
Rarely necessary
Neostigmine, an acetylcholinesterase inhibitor
Due to its relatively low dose and short duration of action
What effect does Atracurium have on intraocular pressure?
Prevents increases in intraocular pressure
This is due to extraocular muscle contraction
What type of neuromuscular blocker is Succinylcholine?
Depolarizing
It mimics acetylcholine at the NMJ
What is a notable side effect of Succinylcholine?
Triggers malignant hyperthermia
It can also cause reported muscular pain following administration
What is the mechanism of action (MOA) of Endrophium?
Inhibits acetylcholinesterases
This increases acetylcholine at the NMJ
What can Endrophium potentially cause?
Cholinergic crisis
This is a result of increased acetylcholine levels.
Characterized by excessive acetylcholine (ACh) accumulation, leading to symptoms like muscle weakness, salivation, and respiratory distress.
Which drugs are inhibitors of acetylcholinesterase?
Neostigmine & Edrophonium
These drugs increase levels of acetylcholine at the NMJ
What does ASA stand for in the context of physical status classification?
American Society of Anesthesiologists
What is ASA level 1 classified as?
Normal healthy patients
Provide examples of ASA level 1.
- No discernible disease
- Animals entered for ovariohysterectomy
- Ear trim
- Caudectomy
- Castration
What is ASA level 2 classified as?
Patients with mild systemic disease
Provide examples of ASA level 2.
- Skin tumor
- Fracture without shock
- Uncomplicated hernia
- Cryptorchidectomy
- Localized infection
- Compensated cardiac disease
What is ASA level 3 classified as?
Patients with severe systemic disease
Provide examples of ASA level 3.
- Fever
- Dehydration
- Anemia
- Cachexia
- Moderate hypovolemia
What is ASA level 4 classified as?
Patients with severe systemic disease that is a constant threat to life
Provide examples of ASA level 4.
- Uremia
- Toxemia
- Severe dehydration and hypovolemia
- Anemia
- Cardiac decompensation
- Emaciation
- High fever
What is ASA level 5 classified as?
Moribund patients not with or without operation
Provide examples of ASA level 5.
- Extreme shock and dehydration
- Terminal expected to survive 1 day malignancy or infection
- Severe trauma
What ASA level for:
* Hx of CHF ____
* Current failure ____
* Renal failure ____
- Hx of CHF = 3
- Current failure = 4
- Renal failure = 3
What is the function of soda lime in a rebreathing system?
Incorporates a CO2 absorbent to remove CO2 from the system and allow exhaled gases to be safely inhaled again
What are the main components of soda lime?
Combination of sodium hydroxide, potassium hydroxide, water, calcium hydroxide
What is the primary component of soda lime?
Na(OH)2 - sodium hydroxide
What type of reaction occurs in soda lime and what are its products?
Exothermic reaction producing H2O, Na2CO3, and heat
What is the intermediate compound formed during the reaction in soda lime?
Carbonic acid
What materials are included in soda lime to give hardness to the granules?
Silica and kieselguhr
What is the optimal moisture content required in soda lime for CO2 absorption?
14-19% H2O
What are the two types of regulation of vapor output in vaporizers?
- Variable bypass (MC)
- Measured flow
Variable bypass is more common, while measured flow is rare.
List the methods of vaporization used in vaporizers.
- Flow-over (MC)
- Bubble-through
- Direct injection
These methods describe how the vapor is generated and delivered.
What are the two locations where vaporizers can be placed in the circuit?
- Out of circuit (MC)
- Rarely integrated
The placement affects how the vapor is utilized in the system.
What is a unique feature of Desfluorane vaporization?
Externally warmed vaporizer with gas phase injected into carrier gas
This specificity distinguishes Desfluorane from other agents.
True or False: Measured flow vaporizers are more common than variable bypass vaporizers.
False
Variable bypass is the more common type.
What is the primary purpose of rebreathing systems?
To remove CO2 from the system and allow exhaled gases to be safely inhaled again
This is achieved using a CO2 absorbent like soda lime.
What type of patients are rebreathing systems reserved for?
Patients >5kg
This indicates that rebreathing systems are not typically used for smaller patients.
What is the function of one-way valves in rebreathing systems?
To prevent immediate rebreathing of exhaled gas
This enables unidirectional flow of gases.
What components are incorporated in rebreathing systems?
- CO2 absorbent (e.g., soda lime)
- One-way valves
- Reservoir bag
- Pressure gauge
- Pop-off valve
- Breathing tubes
These components work together to facilitate safe gas exchange and ventilation.
Fill in the blank: Rebreathing systems incorporate a _______ to remove CO2 from the system.
CO2 absorbent
Soda lime is a common type of CO2 absorbent used.
True or False: Rebreathing systems allow for immediate rebreathing of exhaled gases.
False
One-way valves prevent immediate rebreathing.
What is the role of the reservoir bag in rebreathing systems?
To allow positive pressure ventilation
This helps in delivering the necessary airflow to the patient.
What is the significance of the pop-off valve in rebreathing systems?
To prevent overpressure in the system
It ensures safety by allowing excess gas to escape.
Adjustable pressure‐limiting (APL) valve = “pop-off”
- Releases anesthetic gases into the scavenging system
- Provide pressure control in the breathing circuit during manual ventilation
What is the actual name of the “pop-off”?
Adjustable pressure‐limiting (APL) valve
Fill in the Blank: Internal pressure regulator on ax machine reduces the carrier gas pressure from that in the tank or wall outlet to ____ PSI.
50 PSI
Fill in the Blank: Oxygen tanks are ____ in color in the US.
Green
The green tanks come in E and H. What are there PSI and volume?
E (mini sized tanks) 1900 PSI - 660 L
H (full sized tanks) 2200 PSI - 6900 L
What is the purpose of a non-rebreathing system?
Prevents rebreathing of CO2 by using high fresh gas flow rates
High fresh gas flow rates are essential to ensure that CO2 does not accumulate in the breathing circuit.
What is the required gas flow rate for a non-rebreathing system?
150-300 ml/kg/min
This range is necessary to effectively prevent CO2 rebreathing.
What is the minimum fresh gas flow rate in relation to minute respiratory volume?
At least 3 times the minute respiratory volume
Minute volume (MV) is calculated as MV = RR x TV, where TV is approximately 15 ml/kg.
What is the approximate tidal volume (TV) in ml/kg?
~15 ml/kg
Tidal volume is the amount of air inhaled or exhaled in a single breath.
For which weight range does a non-rebreathing system work best?
Less than 3-5 kg
Non-rebreathing systems are particularly effective for smaller patients.
What is the reservoir bag capacity for rebreathing systems?
5-10 times the tidal volume (10-20 mL/kg)
The reservoir bag size is crucial for accommodating the patient’s breathing needs.
What substance is used in rebreathing systems to absorb CO2?
Soda lime
Soda lime is a common absorbent used in rebreathing systems to eliminate CO2 from the exhaled gases.
Place the local anesthestic in order of chrondrotoxic levels (less to greatest)?
Mepivacaine, Bupivacaine, Ropivacaine
Ropivacaine < Mepivacaine< Bupivacaine
Repeated administration leads to Chondromalacia
What is the dosage of Glyco for IV administration?
0.01 mg/kg IV, 0.005 mg/kg IV
Glyco is administered intravenously at these specific dosages.
Does Glyco cross the blood-brain barrier (BBB) or placenta?
No, Glyco is poorly lipid soluble and does not cross the BBB or placenta
This characteristic differentiates it from atropine.
How does the onset time of Glyco compare to that of atropine?
Glyco has a slower onset (5 min IV) compared to atropine (1 min)
This indicates that atropine acts more quickly than Glyco.
How long do cardiovascular effects last with Glyco compared to atropine?
CV effects last for approximately 1 hour longer with Glyco
This suggests that Glyco has a prolonged effect on cardiovascular parameters.
How does the potency of Glyco compare to atropine?
Glyco is 4 times more potent than atropine (0.04 mg/kg CPA or half dose anesth)
This means a smaller dose of Glyco is required to achieve similar effects.
What are the central nervous system (CNS) effects of Glyco?
Glyco has no CNS or ocular effects
In contrast, atropine can cross the BBB and cause mild sedation.
What is one effect of Glyco on gastric pH?
Increases gastric pH by increasing gastric acid secretions
Atropine does not have this effect.
What is a shared effect of Glyco and atropine?
Both decrease GI motility
This indicates that both agents can affect gastrointestinal function.
What effect do both Glyco and atropine have on lower esophageal tone?
Both reduce lower esophageal tone
This can lead to increased gastroesophageal reflux.
What is a contraindication for the use of Glyco?
Not for use due to reflex brady from alpha 2 agonists
This indicates that Glyco should be avoided in specific clinical situations.
What can epinephrine do to local block?
- Local: Prolong lidocaine by up to 3h
- Epidurals increase duration, rostral spread, faster onset
What is the onset time of Lidocaine when administered subcutaneously (SQ)?
~5 minutes
What is the duration of action for Lidocaine?
45 to 60 minutes
In what forms can Lidocaine be used?
- Nerve block
- Epidural
- IV
- SQ
What effect does Lidocaine have on MAC?
Decreases MAC
What is one of the uses of IV Lidocaine?
- Preventing postoperative ileus
- Stimulates GI motility
What is a ‘Bier block’?
IV regional anesthesia
How is a Bier block performed?
- Apply esmarch bandage to exsanguinate the limb
- Place tourniquet
- Give lidocaine IV distal
What is the toxic dose of Lidocaine for cats?
greater than 6 mg/kg
What is the toxic dose of Lidocaine for dogs?
greater than 8 mg/kg
What are some initial signs of Lidocaine toxicity?
- Vomiting
- Ileus
- Nausea
- Regurge
What are the CNS effects of Lidocaine toxicity?
- Dull mentation
- Seizures
What cardiac issues can Lidocaine toxicity cause?
- Decreased contractility
- Arrhythmia
- Death
What is the duration of action of Bupivacaine?
6-8 hours
Bupivacaine has a longer duration due to its lipophilicity.
What is the onset time for Bupivacaine?
Up to 45 minutes
The onset time is affected by pKa and protein binding.
Is Bupivacaine safe for intravenous administration?
No
Bupivacaine is never given IV due to risk of cardiotoxicity.
What is the potential consequence of accidental IV administration of Bupivacaine?
Cardiac arrest
Intralipid may help in case of accidental IV administration.
What routes can Bupivacaine be safely administered?
SQ, epidurally, or in chest tube
These routes avoid the risks associated with IV administration.
What is the toxic dose of Bupivacaine for cats?
> 2 mg/kg
Dosage above this can lead to toxicity in cats.
What is the toxic dose of Bupivacaine for dogs?
> 4 mg/kg
Dosage above this can lead to toxicity in dogs.
How does the potency of Bupivacaine compare to Lidocaine?
4x as potent
Bupivacaine is significantly more potent than lidocaine.
Dopamine’s MOA
alpha/ beta adrenergic
- Low dose→ Vasodilation (dopaminergic activity)
- Intermediate dose → B receptors → ↑ Cardiac contractility & HR
- High dose → primarily alpha → Vasoconstriction
- Alpha and beta adrenergic receptors are crucial components of the sympathetic nervous system, mediating various physiological responses like vasoconstriction (alpha) and vasodilation/cardiac stimulation (beta)
Dopamine counteracts ____ during anesthesia.
Can use dopamine to counteract vasodilation (hypotension) due to local anesthesia.
Is dopamine inotropic or chronotropic?
High doses of dopamine produce both inotropic and chronotropic effects.
Inotropic affects = cardaic force/ strength
Chronotrpic affects = HR (fast/slow)
Fill in the Blank: NMDA (N-methyl-D-aspartate) receptors are ____ receptors that mediate excitatory neurotransmission.
glutamate receptor
Fill in the Blank: GABA (gamma-aminobutyric acid) is the primary ____ neurotransmitter in the brain
inhibitory neurotransmitter
Discuss adrenergic and dopaminergic receptor distributions, effects, and mechanisms of action
What is the mechanism of action (MOA) of Dobutamine?
- Stimulates beta-1 receptors in the heart, leading to increased heart rate (positive chronotropy) and contractility (positive inotropy). Leads to increased cardiac output and stroke volume.
- Weaker effects and less pronouced on beta-2 receptors, which can cause vasodilation, and alpha-1 receptors, which can cause vasoconstriction.
What is the primary effect of Dobutamine on cardiac contractility?
Strong increase in cardiac contractility
Does Dobutamine cause norepinephrine release?
Does NOT cause NE release (like Dopamine)
What potential side effect may Dobutamine induce in cats?
May induce seizures in cats
What type of chronotropic effect does B1 have?
Positive Chronotrope leading to ↑HR (mild) and inotrophic affect (contractility)
Mechanism of Action of Vasopressin?
Antidiuretic Hormone
H- ormone that plays a crucial role in regulating water balance and bloo
ADH is also known as Arginine Vasopressin (AVP)
What type of receptors does vasopressin act on as a vasopressor?
Nonadrenergic V1 receptors
In what situation may vasopressin be necessary to maintain blood pressure?
Vasoplegic shock associated with sepsis
What is the typical dosage range for vasopressin to maintain blood pressure?
0.1 to 1.0 mU/kg/min
What triggers the release of vasopressin during hypovolemia?
Decrease in blood pressure or blood volume
Low-pressure stretch receptors and baroreceptors are stimulated and trigger the release
What are the two main effects of vasopressin in conditions of low blood volume?
- Increases water retention
- Exerts a powerful vasoconstrictor effect
What is desmopressin?
A synthetic analogue of vasopressin
DDAVP
What effect does desmopressin have on von Willebrand factor (vWf)?
Causes subendothelial vWf release
DDAVP
Can Doxapram trigger an abnormal glottis to open?
No
May be administered to highlight laryngeal function but some dogs will develop severe glottic constriction, resulting in upper airway obstruction
What is Doxapram?
A central nervous stimulant
What effect does Doxapram have on respiratory rate?
Increases respiratory rate
Increases tidal volume
Which part of the brain does Doxapram increase electrical activity in?
Inspiratory and expiratory centers of the medulla
Can stimulate respiration by reflex activitation of cartotid and aortic chemoreceptors
What is the approach used for the Maxillary N.?
- Infraorbital approach
- Intraoral caudal
- Ventral of the rostral Zygomatic arch
A, Infraorbital.B, Maxillary.C, Ophthalmic.D, Mental.E, Mandibular alveolar.
Where is the mandibular foramen located in relation to the teeth?
Between M3 and angular process
A, Infraorbital.B, Maxillary.C, Ophthalmic.D, Mental.E, Mandibular alveolar.
What is the location of the mental foramen for the Inferior alveolar n.?
Between K9 and PM1 at 45 degrees
A, Infraorbital.B, Maxillary.C, Ophthalmic.D, Mental.E, Mandibular alveolar.
Why should you avoided alpha 2-agonist in patients with heart disease?
Alpha 2-agonists can compromise cardiac output (CO) and myocardial oxygen (O2) delivery.
Which cardiac condition should Ketamine not be used in?
hypertrophic cardiomyopathy (HCM)
Ketamine can exacerbate symptoms in patients with HCM.
When can anticholinergics be used in patients with heart disease?
Should not be used, unless symptomatic bradyarrhythmia
Anticholinergics can increase myocardial O2 demand due to potential tachyarrhythmias.
Should lidocaine CRI be used in patients with a 3rd degree block?
No
What drugs should be avoided with adrenal cases?
- Ketamine
- Acepromazine: can causeα-antagonism = complicate sympathetic tone control
- α2-agonist: decrease central sympathetic outflow for pheochromocytoma unpredictable effect
µ-opioid and benzo are preferred
Drugs to avoid with respiratory cases?
Avoid Beta blockers (bronchoconstriction)
Beta-blockers are a class of medications that block the effects of adrenaline (epinephrine) and noradrenaline (norepinephrine) on the body.
Drugs to avoid with renal cases?
- No NSAIDs
- Ketamine, Benzos, Opioids, Acepromazine all of them renal excretion =prolong effects
- Avoid ⍺-2s in obstructed cases bc ↑ urine output
- No epidurals w/ severe uremia (PLT dysfunction)
Why would you avoid epidurals in uremic patients?
May have PLT dysfunction
Drugs to avoid with Septic cases?
- NO ACE OR ⍺-2s (CV changes)
- Etomidate – adrenal suppression (if used give Dex SP)
What is malignant hyperthermia (MH)?
A rare, inherited disorder that causes a severe, life-threatening reaction to certain anesthetics and muscle relaxants used during surgery
MH is characterized by a hypermetabolic state leading to various physiological disturbances.
What are the key symptoms of malignant hyperthermia?
Hypercarbia, hyperthermia, muscle rigidity, cardiac arrhythmias, and can lead to death
These symptoms arise due to excessive calcium release and increased metabolic activity.
Which cellular defect is associated with malignant hyperthermia?
Defect in the Ryanodine Receptor (RYR1)
This receptor is crucial for Ca induced Ca release in muscle cells.
What is the first sign of malignant hyperthermia?
Abrupt increase in CO2 from increased metabolism
This is followed by an increase in temperature and heart rate.
What are the trigger agents for malignant hyperthermia?
Succinylcholine (depolarizing muscle relaxent) and Halothane (Sevoflurane, Isoflurane)
These agents can provoke a hypermetabolic crisis in susceptible individuals.
What is the primary therapy for malignant hyperthermia?
D/C inhalants and administer IV Dantrolene
Dantrolene stabilizes the sarcoplasmic reticulum membrane and decreases calcium release.
What does Dantrolene do in the context of malignant hyperthermia?
Stabilizes sarcoplasmic reticulum membrane and decreases calcium release
This action helps to mitigate the severe muscle rigidity and metabolic crisis.
What is TIVA and how is it used in malignant hyperthermia?
Total Intravenous Anesthesia (TIVA) with propofol and oxygen delivery with a well-flushed system
This technique avoids the use of inhalational agents that could trigger MH.
How can patients be pretreated for elective surgeries to prevent malignant hyperthermia?
Oral dantrolene for 1 week prior
This pre-treatment can help reduce the risk of MH during anesthesia.
What should be assumed about relatives of individuals with malignant hyperthermia?
They may also have the disorder
It is an inherited condition, so genetic counseling may be necessary.
What is Alfaxalone?
Steroid anesthetic which enhances GABA and glycine mediated CNS depression
Alfaxalone is used for its anesthetic properties in veterinary medicine.
How is Alfaxalone administered?
Neutral solution can go IV or IM but only stored 6 hours
Alfaxalone’s stability limits its storage and usage timeframe.
How does Alfaxalone compare to propofol?
- Alfaxalone has less apnea compared to Propofol
- Can use like propofol → rapid metabolism
Both are used for inducing anesthesia but differ in their metabolic pathways.
What are the cardiovascular and respiratory effects of Alfaxalone?
Cardiac and respiratory depressive
Use with caution in patients with pre-existing conditions affecting these systems.
What is the incidence of apnea with Alfaxalone compared to propofol?
Apnea, less than propofol
This indicates a potentially safer profile in terms of respiratory depression.
What is the drug schedule classification of Alfaxalone?
Schedule IV
This classification affects its regulation and use in clinical settings.
Fill in the Blank: Patients that have ____ should avoided using Alfaxalone?
DCM
DCM refers to dilated cardiomyopathy, a condition that may be exacerbated by the drug’s effects.
What is the primary route of metabolism for Propofol?
EXTRA-hepatic metabolism
Metabolism occurs outside the liver.
Propofol is ____ acting and causes ____ and ____ if given as a bolus.
- Fast acting
- Hypotension (secondary to vasodilation) and Apnea
It has a rapid onset of effects.
True or False: Propofol causes oxidative damage to RBC in cats.
Yes, but the Oxidative damage to RBC is not clinically significant and does not lead to anemia.
True or False: Propofol cause spinal myoclonus?
True
Spinal myoclonus, is a movement disorder characterized by sudden, brief, involuntary muscle jerks or twitches, involuntary muscle contractions (aka myoclonus) originating from the spinal cord, often involving specific segments.
What conditions can Propofol be used to treat?
Refractory status epilepticus and reduces intracranial pressure
It is utilized in critical care situations.
Is Propofol considered a controlled substance in the United States?
Yes, in some states
Regulations may vary by state.
What happens to the tissue when Propofol is administered perivascularly?
Nothing to the tissues. It does not cause tissue damage
This route is safe for administration.
What is the potency of Methadone compared to morphine?
2x
Methadone is a 𝜇 agonist and NMDA blocker, causing less excitatory response in cats.
What is the potency of Hydro compared to morphine?
8x
Hydro is a 𝜇 agonist.
What is the potency of Oxymorphone compared to morphine?
10x
Oxymorphone is a 𝜇 agonist.
What is the potency of Buprenorphine compared to morphine?
40x
Buprenorphine is a Partial 𝜇 agonist.
What is the potency of Fentanyl compared to morphine?
100x
Fentanyl is a 𝜇 agonist.
What is the potency of Meperidine compared to morphine?
10x less
Meperidine is a 𝜇 agonist and causes more histamine release.
Does Buprenorphine has a plateau effect?
Yes.
Ceiling effect, higher doses just last longer.
Methadone
A mu agonist and an NMDA receptor antagonist which causes fewer excitatory responses in cats
Less excitatory effects in cat’s vs dogs
2x as potent as morphine
What is the effect of a mixture of helium and oxygen (heliox) on respiratory effort?
It reduces respiratory effort by having lower resistance to flow than either room air or 100% oxygen.
Increases tendency to laminar flow and reduces resistance to turbulent flow.
What is the ratio of helium to oxygen used?
70:30 ratio of helium to oxygen.
Prevent fires caused by laser ignition
What are the three main types of one lung ventilation?
- Double-lumen tubes (DLTs)
- Bronchial blockers (BBs)
- Single-lumen tubes (SLTs)
Standard long ETT are less desirable
With DLT one lung ventilation what is a limiting factor?
Size
DLTs limited to 5-20 kg
Confirm placement with a bronchoscope +/- thorascopic assistance – then ventilate each lung field and listen
What is the purpose of a breathing/rebreathing bag?
Provides compliant reservoir of gas that changes volume with the patient’s inspiration/expiration
What is the ideal volume for a rebreathing bag?
10-20 mL/kg (5-10x tidal volume) ≈ Vmin
10-20 mL/kg
Why should a rebreathing bag not be too large?
It becomes difficult to observe the bag moving with breathing
What are the cardiovascular effects of opioids?
Minor direct effects
Opioids primarily cause bradycardia through centrally mediated increased parasympathetic nervous system activity.
What can happen if a bolus of opioids is administered?
Bradycardia due to centrally mediated ↑ PSNS activity
This effect can be blocked by anticholinergics.
Can opoids lead to histamine release?
Yes.
IV use can cause vasodilation, tachycardia, and hypotension, especially with Meperidine and Morphine.
How much can opioid administration decrease MAC?
By 40-60%
MAC stands for Minimum Alveolar Concentration, a measure of anesthetic potency.
Whether locals are administered in the central neuraxis (epidurally, intrathecally), or systemically all
- ** Inhibit K+ and Ca2+ channels** at the level of the dorsal horn of the spinal cord
- inhibit substance P binding and evoked ↑ intracellular Ca2+
- inhibit glutamatergic transmission in the spinal dorsal horn neurons – reducing NMDA and neurokinin-mediated postsynaptic depolarization
What is the effect of low lipophilicity on the duration of action (DoA) of drugs?
Drugs with low lipophilicity have a longer duration of action (DoA)
Example: Morphine is cited as a drug with low lipophilicity.
How does lipid solubility and protein binding affect systemic absorption of drugs?
Greater lipid solubility and protein binding result in lower systemic absorption
This implies that drugs that are more lipid-soluble and strongly bound to proteins may not be absorbed as effectively into the systemic circulation.
How do local anesthetics work?
- Vasodilation occurs first →
- Loss of sensation of temperature →
- Loss of sensation of sharp pain →
- Loss of sensation of light touch →
- Loss of motor activity
Fill in the Blank: ____ opioids, when given epidurally, have a slower onset of analgesia and a longer duration of effectiveness compared to more lipophilic opioids.
lipophilic opioids
Fill in the Blank: Lipophilic opioids, when given epidurally, have a ____ onset of analgesia and a ____ duration of effectiveness compared to more lipophilic opioids.
Slower onset
Longer duration
What can epidural anesthesia cause?
Sympathetic blockade and hypotension
This means the sympathetic nervous system’s function is impaired, leading to low blood pressure.
What should be given to offset hypotension caused by epidural anesthesia?
IV fluids
Administering intravenous fluids helps to increase blood volume and blood pressure.
Giving a large volume with a long-lasting local anesthetic can lead to?
Result in paralysis of the intercostal nerves, leading to impaired respiration
Intercostal nerves are responsible for the movement of the chest wall.
What medication can be used to counteract vasodilation due to local anesthesia?
Dopamine
Dopamine can help restore vascular tone and improve blood pressure.
What is the perferred benzodiazepine for dogs with hepatic dysfunction?
Midazolam
MOA- enhance GABA - gamma-aminobutyric acid (inhibitory neurotransmitter)
Where do epidural injections go?
Epidural Space
The procedure involves palpating the wings of the ilium and the dorsal spinous processes of L7 and S1, and advancing through supraspinous and interspinous ligaments.
What is the order of lipophilicity for the following drugs: Buprenorphine, Fentanyl, Hydro, Morphine?
Buprenorphine > Fentanyl > Hydro > Morphine
This ranking indicates the relative solubility of these drugs in lipids.
Why is morphine preferred for epidural analgesia?
Because of its relatively low lipophilicity
Morphine provides analgesia for 12 to 24 hours by this route.
True or False: Fentanyl is commonly used in epidurals.
False
Fentanyl is very lipid soluble and not used in epidurals.
Contraindications for a epidurals?
C – coagulopathy
H – hypotension, hypovolemia
I – infection, inflammation
N – neoplasia
A – anatomical abnormality
Adverse effect of epidurals?
- neural damage or neurotoxicity,
- infection,
- subarachnoid, spinal, or subdural injection,
- IV injection,
- hypotension,
- bradycardia,
- Horner’s syndrome,
- resp depression,
- total spinal anesthesia,
- toxicity,
- urinary retention
Thoracic breathing – if a large volume is use affecting diaphragm (Paralysis)
Ketamine MOA?
- Acts on NMDA, opioid, monoaminergic, and muscarinic receptors
- Noncompetitive antagonists at NMDA R
- Act at mu, delta, and kappa opioid Rs
Also interact with votlage gated Ca channels
True or False: Ketamine safe to use w/ epidural.
True
Better somatic (vs. visceral) pain control
Does Ketamine have better somatic pain control or visceral pain control?
Better Somatic pain control
Tramadol
- Weak µ agonist
- Analgesic properties through inhibition of reuptake of Serotonin and NE (adrenergic receptor effects within CNS)
Motablized in liver and excreted renally. Is 30% excrete unchanged in kidneys.
What percent of the Tramadol is excreted unchanged via the kidney’s?
30%
MAC of isoflurane, sevoflurane and desflurane?
“MAC” (Minimum Alveolar Concentration) is the minimum alveolar concentration of an inhaled anesthetic required to prevent movement in response to a standardized noxious stimulus in 50% of patients
What begins Stage III of anesthesia?
Cessation of muscular movement and onset of regular pattern of breathing
This stage is crucial for surgical procedures.
What is the goal plane for anesthesia?
Plane 2
Plane 3 is also acceptable but indicates a deeper level of anesthesia.
At what plane does the palpebral reflex disappear?
Plane 2 (light-medium)
The palpebral reflex is an important indicator of anesthesia depth.
At what plane does the pupillary light reflex (PLR) disappear?
Plane 3 (deep medium)
Loss of PLR indicates a deeper level of anesthesia.
Fill in the blank: Stage III of anesthesia is characterized by _______.
cessation of muscular movement
This is a key feature that allows for surgical intervention.
True or False: Plane 3 of anesthesia is considered too deep for surgical procedures.
False
Plane 3 is acceptable but indicates a deeper level of anesthesia.
What does end-tidal CO2 provide an estimate of?
Arterial CO2
What is required to deliver CO2 to the alveoli?
Perfusion of the alveoli
How can end-tidal CO2 monitoring be used in clinical settings?
To indicate changes in pulmonary perfusion and cardiac output
What are the three factors associated with end-tidal CO2 monitoring?
- Ventilation
- Leak
- Arrest
Consider this:
* CO2 Production
* Alveolar Ventilation
* Pulmonary perfusion
* Apparatus malfunctioning (Leak)
* Arrest
End-tidal CO2 is typically ____ mmHg less than PaCO2.
3-6