Anatomy - skeletal system Flashcards
What are the three components of the skeletal system
Bone, Cartilage and ligaments
Bone matrix
hardened matrix (mineralised or calcified) by calcium phosphate and other minerals.
Cartilage
forerunner of most bones especially during child to adult development, it covers many bones at joint surfaces
LIgaments
they hold different bones together
How can bones be considered
individual organs consisting of many tissues like Osseous tissue, blood, bones marrow, cartilage, adipose, nervous tissue, fibrous, tissue.
What are the five functions of the skeleton
Support (hold up body, muscles and other structures) Protection ( enclose and protaect brain spinal cord, marrow, heart, viscera) Electrolyte balance ( stores and releases calcium and phosphate ions when required) Acid-base balance ( buffers blood agains excessive pH changes by releasing alkaline salts) blood formation ( red bones marrow makes blood, haemopoietic)
What are the four types of bone
long bone (Femur, Ulna) short bone (Capitate, Talus) flat bone (Scapula, Sternum) irregular bone (Sphenoid bone, vertebra)
Features of long bones
hard shell of compact bone (periosteum and endosteum)
Medulary / marrow cavity - bone marrow in center and spongy bone at ends
Long bones are divided into …
Epiphysis
Diaphysis
and they have an Epiphyseal line
(metaphysis)
Features of Short bones
Diploe
Periosteum - on both sides
Endosteum - lining the diploe
What is on osteon
cylindrical units of the COMPACT BONE with a central canal for nerves and vessels, and then concentric lamella ( layers) containing osteocytes in lacunae which are connected via canaliculi.
What are the four types of bone cells
Osteogenic
Osteoblasts
Osteocytes
Osteoclasts
Osteogenic cells
Stem cells found in the endosteum, inner periosteum and central canals that give rise to osteoblasts.
Osteoblasts
Cells that form bone, they are found in the inner periosteum and in the endosteum, they are non-mitotic, they synthesise the organic bone matrix and they increase in number in response to damage or mechanical stress.
Osteocytes
They are trapped in the matrix and have finger like cytoplasmatic projections for communication and sensing of mechanical stress.
Osteoclasts
They originate from bone marrow stem cells
They reabsorb done
Composition of the Bone Matrix
1/3 Organic - mainly collage and provides flexibility
2/3 Inorganic - 85% hydroxyapatite (Calcium phosphate), 10% calcium carbonate and other salts provides strength
Spongy Bone
It is made of Spicules and trabeculae, contains bone marrow and it is low weight and high strenght
Bone Marrow
Red is haemopoietic
Yellow isn’t but is rich in adipocytes and stores triglycerides.
How is Calcium regulated
Calcium is regulated by:
Cacitriol - causes increase in blood calcium levels
Calcitonin - reduced osteoclast activity and increases osteoblast activity -> causes BLOOD FORMATION (calcium levels drop bc used to make bone)
Parathyroid Hormone - causes increase in osteoclast activity and reduced osteoblast activity -> promotes BONE RESORPTION (so increases blood calcium levels)