analgesic

Question 1

what are the 2 forms of COX?

Answer 1

cox-1
cox-2

Question 2

cyclooxygenase can be inhibited by?

Answer 2

aspirin
anti-inflammatory drugs

Question 3

diclofenac and Meloxicam are non-selective cox-1 inhibitors
true or false?

Answer 3

false, cox-2 inhibitors

Question 4

aspirine is irreversible COX-1 and
COX-2 inhibition
true or false?

Answer 4

true

Question 5

what are the 4 mechanism of action for aspirin?

Answer 5

antithrombotic effect)
antipyretic,
anti-inflammatory,
and analgesic effect

Question 6

High dose (2400-4000 mg/d) of aspirin has?

Answer 6

anti-inflamm effect

Question 7

what is the most common effect of aspirin?

Answer 7

gastric acid damages tissue

Question 8

give examples of cox-2 inhibitors

Answer 8

– Celecoxib
– Etoricoxib
– Parecoxib

Question 9

paracetamol is not used in inflammatory painful conditions
true or false?

Answer 9

true

Question 10

what are the main Opioids ?

Answer 10

• Morphine
• Codeine
• Tramadol

Question 11

µ -most relevant as all
clinically used opioids
exert their action via the
µ -opioid receptor
true or false?

Answer 11

true

Question 12

the action of opioids is Leading to reduction in excitability of neurons and inhibition of pain signals, resulting in ?

Answer 12

reduction of pain perception

Question 13

what is the most common administration of opioids?

Answer 13

systemically, intravenous, intramuscular

Question 14

what can be used for overdosed of opioids leading to toxicity?

Answer 14

naloxone, antagonist of opioids