Anaesthetics Flashcards
what is nociceptive pain?
normal response to perceived or actual injury to the tissues, occurs in normally functioning nervous system, leads to perception of pain
what are nociceptors?
Agamma and C fibre free endings
what is chronic pain described as?
over 12 weeks or beyond normal course of how long it should last, can be caused by cancer
what do C fibres transmit
dull pain
which tracts carry nociception?
spinothalamic
spinoreticular
how does tissue injury cause pain?
directly-inflammation and damage to surrounding tissue
indirectly-damage>membrane lipids broken down by phospholipase A2>arachidonic acid, COX changes it to prostaglandins> stimulate nociceptors
chronic pain types?
cancer complex regional pain syndrome MSK persistant post op diffuse idiopathic
where is pain signalled to
pons and midbrain (periaqueductal grey, nucleus raphe magnus and locus coerleus) and the thalamus>sensory cortex
where do we become aware of pain?
when it reaches somatosensory and anterior cingulate cortices
which laminae are pain signals transmitted to?
I and II