Anaemia Flashcards
What is anaemia
A decreased number of RBC in the blood
HB in men (anaemia)
<130
HB in women (anaemia)
<120, <110 in pregnancy
Common causes of anaemia
-Diet insufficiencies, systemic disease,
-primary bone marrow disorders,
-autoimmune conditions,
-primary abnormalities of erythrocytes
-blood loss
types of WBC
- Lymphocyte
- Monocyte
- Eosinophil
- Basophil
-Neutrophil
Immature RBC called
reticulocyte
Mature RBC lifespan
120d
Primary function of the erythrocyte
Fight infection
Aid blood clotting
transport b12
transport Co2 and O2
how many oxygen molecules can one rbc carry
4
Clinical signs of anaemia
Fatigue
Dizziness
Headaches
SOB
Lethagy/weakness
Compensatory tachycardia
Bounding pulse/palpitations
Visual clinical exam of anaemia - skin
Pale palmar creases
Dermatitis
Pallor
Jaundice
leg ulcers, peripheral neuropathy
Visual clinical exam of anaemia - cardiac
Palpitations, Pitting oedema, New onset or worsening angina
Visual clinical exam of anaemia - hands
Clubbing, nail discoloration, koilonychia
Visual clinical exam of anaemia - abdo
Splenomegaly
Visual clinical exam of anaemia - mouth
Glossitis
Angular Stomatitis
3 primary causes of anaemia
Reduced production of rbc
haemolysis
haemorrhage
Reduced production of RBC Causes
nutrient deficiency
hormone deficiency
disease or other conditions
Haemolysis is
excessive rbc destruction, often hereditory
haemorrhage caused by
excessive blood loss
GI ulcers
Menstrual heavy loss
OD of aspirin
etc
MCV stands for
mean cell volume
MCV tests what
average size of rbc
MCV 80-100
normocytic
MCV <80
Microcytic
MCV >100
Macrocytic
MCH stands for
mean cell haemoglobin
MCH means
Average concentration of haemoglobin in RBC,
the colour of the cells
low MCH =
hypochromic
Microcytic, hypochromic anaemias cause
IDA, anaemia of chronic disorders, thalassaemia, sideroblastic anaemia
Macrocytic, normochromic anaemia cause
B12 deficiency, folate deficiency, alcohol excess, liver disease, thyroid disease
normocytic, normochromic anaemia causes
anaemia of chronic disease, acute blood loss, early iron deficiency, anaemia of renal failure
a low reticulocyte count would suggest problems with ?
bone marrow
reticulocyte is an index of what
the bone marrow health and response to anaemia
reticulocyte helps differentiate what
an anaemia that occurs because of bone marrow failure vs haemorrhage or haemolysis