Aminoglycosides And Nitromidazole Flashcards

1
Q

Aminoglycosides (gentamicin) MOA and Uses

A

Displaces cations in the membrane inhibiting protein synthesis
USES: Aerobic Gram negative bacilli, UTI, respiratory tract, skin and soft tissue, sepsis due to gram negative bacilli

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2
Q

Aminoglycoside (gentamicin) side effects

A

Renal failure, auditory impairment, neuromuscular blockage

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3
Q

Nitroimidazole (Flagyl) MOA and clinical use

A

MOA: Promotes formation of free radicals, and cytotoxic particles fatal to DNA
USE: Anaerobes, Travelers diarrhea, urethritis/STI

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4
Q

Nitroimidazole (Flagyl) avoid use and SE

A

Avoid use in c.diff
SE: Metallic taste, furry tongue, glossitis, stomatitis, seizures, peripheral neuropathy, dizziness, encephalopathy

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