Aminoglycosides And Nitromidazole Flashcards
1
Q
Aminoglycosides (gentamicin) MOA and Uses
A
Displaces cations in the membrane inhibiting protein synthesis
USES: Aerobic Gram negative bacilli, UTI, respiratory tract, skin and soft tissue, sepsis due to gram negative bacilli
2
Q
Aminoglycoside (gentamicin) side effects
A
Renal failure, auditory impairment, neuromuscular blockage
3
Q
Nitroimidazole (Flagyl) MOA and clinical use
A
MOA: Promotes formation of free radicals, and cytotoxic particles fatal to DNA
USE: Anaerobes, Travelers diarrhea, urethritis/STI
4
Q
Nitroimidazole (Flagyl) avoid use and SE
A
Avoid use in c.diff
SE: Metallic taste, furry tongue, glossitis, stomatitis, seizures, peripheral neuropathy, dizziness, encephalopathy