Ageing of Orofacial Tissues Flashcards
1
Q
2 types of ageing process that affect the skin
A
- intrinsic (natural) ageing (genetic, continuous)
- external (sun, smoking)
2
Q
physiology of intrinsic ageing
A
- collagen production slows
- elastin less elastic
- less new cell turnover
- benign neoplasms
3
Q
sign of intrinsic ageing
A
- dry, pale, thin, transparent skin
- fine wrinkle
- sagging
- loss of underlying fat –> hollow cheeks/ eye sockets
- itchy skin
4
Q
when does loss of muscle begin
A
4th decade of life (40s)
5
Q
average lifespan of osteocytes
A
35 yrs
6
Q
what does the senescence-accelerated mouse (SAM) model show
A
model of accelerated ageing:
IGF1 decreases with age –> less cellular proliferation, regeneration, would healing
7
Q
3 types of oral mucosa
A
- masticatory: attached gingiva, hard palate
- lining: lips, cheek, alveolus, FOM, soft palate, ventral tongue
- specialised: gustatory mucosa of tongue, vermillion zone of lip
8
Q
what is a fordyce spot
A
subaceous glands (increase with age on oral mucosa)
9
Q
where is collagen content INCREASED with age
A
- tongue
- gingiva (in lamina propria)
10
Q
what contributes to mucosal lesions 3
A
- mucosal senescence
- salivary gland senescence
- immuno-senescence (dec immunity, inc autoimmunity)
11
Q
name a tissue that increases in size with age
A
cementum (x3 16-70yo)
12
Q
what proteins do aged periodontal fibroblasts express 2
A
cytokeratin
plus vimentin
