Adrenergic and Cholinergic Effects of CNS Drugs

Question 1

BBB exists to maintain homeostasis in the environment surrounding neurons and to prevent neurotransmitters from escaping

Answer 1

ok

Question 2

BBB breaks down with aging

Answer 2

truth

Question 3

What kinds of conditions can cause temporary BBB breakdown?

Answer 3

• Post- MI leading to cerebral edema
• Following marked rise in BP
• After injection of hypertonic solutions

Question 4

Structure of BBB

Answer 4

• Brain capillary endothelium with endothelial cells containing lots of metabolic enzymes to break down drugs
• Tight junctions between endothelial cells
• Astrocyte vascular feet processes

Question 5

What gets through the BBB

Answer 5

Lipophilic molecules that are non-protein bound, un-ionized drugs, gasses, water

Question 6

Evidence now shows that sub-concussive collisions in football players can can lead to disruption of the BBB integrity, leading to a surge in the astrocytic protein S100B in blood,

Answer 6

ok

Question 7

We knbow that lipophilicity is important for a drug to gain access to the CNS. How is it measured experimentally>

Answer 7

Octanol/Water partition coefficient…the higher the coefficient, the more easily the drug is absorbed

Question 8

Why do lipophilic drugs have such long elimination times but such short durations of action

Answer 8

Long time for elimination because they are stored quickly in adipose tissue.
Short duration of action because they quickly distibute to a large volume of distribution.
Quick in Quick out…Quick to highly perfused organs (brain, heart, kidney) quick to perfuse out of them

Question 9

What the fuck is P-GP

Answer 9

A drug efflux pump that keeps drugs out of the brain.