Adrenergic Agents Flashcards
Beta-Adrenergic Blocking Agents do what?
Competitive blocking of the beta-receptors in the SNS
Blocking of beta receptors in the heart and juxtaglomerular apparatus of the nephron
What are the indications for beta-adrenergic blocking agents?
Treating:
Cardiovascular problems, hypertension, angina, and migraine headaches
Preventing:
Reinfarction after MI
What are the contraindications of prescribing beta-adrenergic blocking agents?
- Diabetes
- Bradycardia
- Heart block
- Shock
- CHF
- COPD
- Asthma
- Pregnancy and lactation
What two things would cause a prescriber to use caution when prescribing beta-adrenergic blocking agents?
Diabetes
Hepatic dysfunction
What are the adverse reactions associated with beta-adrenergic blocking agents?
- Fatigue, dizziness, depression, sleep disturbances
- Bradycardia, heart block, hypotension
- Nausea, vomiting, diarrhea
- Decrease libido
What drugs interact with beta-adrenergic blocking agents?
Clonidine
NSAIDs
Insulin or anti diabetic medications
What is the prototype drug for beta-adrenergic blocking agents?
Propranolol
What is the advantage of beta 1 selective adrenergic blocking agents?
They do not usually block beta 2 receptor sites including the sympathetic bronchodilation
What is the indication that a patient should be put on beta 1 selective adrenergic blocking agents?
Hypertension
Angina
Some cardiac arrhythmias
Who is the preferred patient to be prescribed beta 1 selective adrenergic blocking agents?
Those who smoke, have asthma, obstructive pulmonary disease, or seasonal allergic rhinitis.
What are the contraindications for prescribing beta 1 selective adrenergic blocking agents?
Sinus bradycardia Heart block Cardiogenic shock CHF Hypotension
When should a prescriber use caution when prescribing beta 1 selective adrenergic blocking agents?
COPD
Diabetes
Thyroid disease
What drugs have interactions with beta 1 selective adrenergic blocking agents?
NSAIDs
IV lidocaine
What is the prototype for beta 1 selective adrenergic blocking agents?
Atenolol
What are the adverse effects associated with atenolol?
Dizziness Bradycardia Heart Failure Arrhythmias Gastric pain Flatulence Impotence Bronchospasm Decreased exercise tolerance