Adrenergic

Question 1

vasodilator drugs

Answer 1

1. hydralazine

2. isosorbide dinitrate

Question 2

hydralazine action

Answer 2

arterial vasodilation

decrease afterload

Question 3

isosorbide dinitrate action

Answer 3

venous vasodilation

decrease preload

Question 4

Compared to ACE-inhibitors, hydralazine-ISDN equally improved

Answer 4

EF, but ACE-inhibitor had a greater reduction in mortality.

Question 5

The fixed dose of hydralazine-ISDN reduced

Answer 5

mortality in AA receiving beta blocker, ACE-inhibitor and a aldosterone antagonist. (A-HeFT)

Question 6

In blacks, difference are seen that may effect drugs.

Answer 6

1. TGFB mRNA
2. increased endothelin 1
3. decreased role of RAA
4. NO deficiency

Question 7

the combination of hydralazine and isosirbide dinitrate is recommended to reduce morbidity and mortality for

Answer 7

patients self described as african americans with NYHA class 3-4 HFrEF receiving optical therapy with ACE inhibitors and BB 
(unless contraindicated)

Question 8

ACE inhibitors drug interactions

Answer 8

1. Lithium
2. NSAIDs
3. Salt Substitutes
4. Loop Diuretics
5. K+ sparing Diuretics

Question 9

ACE inhibitors use caution with

Answer 9

elderly patients

Question 10

enaloprol vs hydralazine mortality

Answer 10

mortality is lower with enaloprol

Question 11

enaloprol reduced

Answer 11

risk of disease and mortality
BUT you get bigger bang for your buck in sicker patients. Doesn't seem to help class 1 very much

Question 12

ACE inhibitors are recommended in patients with

Answer 12

HFrEF and current or prior symptoms (unless contraindicated) to reduce morbidity and mortality

Question 13

ARBS are

Answer 13

angiotensin receptor blockers

Question 14

ACE inhibitors reduce the risk of

Answer 14

secondary HF development

Question 15

ARB side effects

Answer 15

1. well tolerated
2. less angioedema,
3. no cough
4. hyperkalemia
5. uricosuric effects