Addiction: Methods Of Modifying Flashcards
What are the 2 Methods of Modifying Addiction.
- Agonist + Antagonist Substances
2. Aversion Therapy
Describe a Agonist Substance.
- A chemical that binds to a postsynaptic receptor and activates that receptor to produce a response
- In medication, agonists are designed to imitate the action of another substance (e.g. heroine)
- Example = Methadone - used to treat addiction to opioid drugs + is produced synthetically to mimic same effects
What are the Uses of Methadone (Agonist Substances)?
- Aims to reduce cravings + to prevent withdrawal symptoms
- Similar effects of Heroine without high
- Dosage reduced over time until stopped completely
Describe the Dosage of Methadone (Agonist Substances)
- NICE suggest to give an initial dose of 10-40mg + increase by 10mg until no signs of withdrawal (60-120mg)
- Given orally
- Doctor checks patient everyday for first 3 months then once a week
Describe a Antagonist Substance.
- Binds to receptors + blocks usual function of particular substance
- Example = Naktrexone - used in abstinence stage of recovery - blocks euphoric + pleasurable effects associated with opioid (less rewarding)
What is the Usage of Naltrexone (Antagonist Substances)?
- Used for people who have stopped using opioids
- Given orally - available as an implant/injection in US + Russia
- Can be used for up to 6 months
- Can also be used for alcoholics
- NHMRC suggests it for problematic gamblers
Agonist + Antagonist Substances Evaluation
Effectiveness
1. Effectiveness of Methadone
- POSITIVE
- NICE assessed 31 reviews of the effectiveness of Methadone (including 27 randomised controlled trials) - found higher levels of retention using Methadone than placebo/no treatment
- Providing that the Dosage is adequate the Methadone is an effective as a maintenance treatment
Agonist + Antagonist Substances Evaluation
Effectiveness
2. Comparing Methadone + Buprenorphine
- Point to consider
- Alternative to Methadone = buprenorphine - milder + has agonist + Antagonist properties
- Less risk of overdose due to ceiling effect
- Marteau (2015) = analysed data for 5 years - 6X safer than Methadone
- Methadone still preferred treatment - higher rate in retaining patients in treatment because the addict prefers the feeling they get from taking Methadone so are more likely to continue taking it
Agonist + Antagonist Substances Evaluation
Effectiveness
3. Effectiveness of Naltrexone
- NICE reviewed 17 studies concerning effectiveness of Naltrexone for heroine addiction - conflicting results - many randomised controlled trails showed no significant difference
- Naltrexone was associated with reduction in relapse rates particularly those were highly motivated
- Lahti (2011) = tested effectiveness of Naltrexone on sample of gamblers - instructed to take it before gambling + felt urge to gamble - found significant decrease in gambling levels - more research needed
Agonist + Antagonist Substances Evaluation
Effectiveness
4. Issues with Effectiveness
- NEGATIVE
- NICE identified problems with research in the effectiveness of Methadone + Naltrexone- studies from different countries are compared there may be differences in treatment protocol (e.g. dosage)
- Studies don’t follow up over a long period of time - common to relapse within months/years - researcher may not pick up on this - sample attrition is also common
Agonist + Antagonist Substances Evaluation
Ethical Issues
1. Ethical Criticisms of the Use of Methadone
- NEGATIVE
- May interact with other drugs (e.g. alcohol+antidepressants) to cause respiratory problems
- Danger of overdose if addict combines methadone with other drugs
- Office for National Statistics reported that in 2013 methadone was responsible for 429 deaths in UK
Agonist + Antagonist Substances Evaluation
Ethical Issues
2. Side Effects of Naltrexone
- NEGATIVE
- Greater risk of overdose if individual chooses to return to taking a drug they will need more to feel the same effects + more likely to overdose
Agonist + Antagonist Substances Evaluation
Social Implications
1. Financial Cost of Methadone to Society
- NEGATIVE
- Centre for Policy Studies says prescribing methadone was an expensive failure - costs society money for methadone + 320000 drug users on benefits - greater success achieved through funding rehabilitation centre
- HOWEVER
- DrugScope claims report overestimated cost of prescribing methadone - National Audit Office described treatment as a good value for money (for tax payer) - addict able to function in society as makes addiction more manageable
Agonist + Antagonist Substances Evaluation
Social Implications
2. Methadone + Criminality
National Treatment Agency - treating heroine users with methadone has an immediate positive effect on society by reducing criminality - rates of offending are reduced by 1/2 when addicts are in treatment
- Setting up methadone programmes centered around a particular area - people worried about possible increased crime
- Boyd (2012) = treatment centres in Baltimore - crime rates were similar to surrounding area
What is Aversion Therapy?
- Helps individual to unlearn addictive behaviours by changing association
- Based on principles of classical conditioning
- Less popular as a treatment