Addiction Flashcards

1
Q

ICD-10 criteria of dependence

A
  1. strong desire to take substance
  2. difficulties controlling substance use
  3. physiological withdrawal state
  4. tolerance
  5. neglect of alternative pleasures
  6. persistent despite evidence of harm
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2
Q

what is tolerance and how does it develop?

A

repeated dopamine release, receptors down-regulate so threshold is increased and normal experiences don’t evoke pleasure response

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3
Q

define lapse

A

single event

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4
Q

define relapse

A

falling into old pattern of behaviour

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5
Q

define conditioning

A

process of behaviour modification where an individual associates a desired behaviour with a previously unrelated stimulus

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6
Q

two types of conditioning

A
pavlov= classical conditioning
skinner= operant conditioning
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7
Q

define reinforcement

A

increases frequency of behaviour

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8
Q

positive reinforcement

A

positive reward e.g. feeling more relaxed after using

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9
Q

negative reinforcement

A

getting rid of withdrawals

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10
Q

positive punishment

A

being shouted at

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11
Q

negative punishment

A

losing family or home

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12
Q

define habit

A

acquired pattern of behaviour regularly followed until it becomes almost involuntary

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13
Q

thinking errors/ unhelpful ideas

A
permission-giving
minimisation 
rationalisation
denial
blame
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14
Q

what is the biopsychosocial model?

A

basic formation consists of presenting problems, predisposing, precipitating, protective and maintaining factors to do with addiction

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15
Q

define hazardous drinking

A

drinking alcohol in a way that increases risk of harm (>14 units/week)

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16
Q

define harmful drinking

A

drinking >35 units/week

17
Q

calculate alcohol units

A

strength (ABV %) x volume (ml) divided by 1,000

18
Q

screening for alcohol use

A

FAST
AUDIT
CAGE (dependence)

19
Q

management of alcohol dependence

A

brief interventions e.g. services

motivational interveiwing

20
Q

what causes alcohol withdrawal

A

CNS depression from alcohol

21
Q

what does a sudden stop in alcohol intake cause?

A

unopposed excitation with decreased GABA and increased glutamate that is toxic to cells

22
Q

presentation of alcohol withdrawal

A
24-48 hours
restlessness
tremor
sweating
N&V
insomnia
tachycardia
hypertension
generalised seizures
23
Q

presentation of DTs

A
confusion
hypertension
fever
hallucinations
paranoid ideation
cardiovascular collapse
infection
24
Q

management of alcohol withdrawal

A

BZDs
analgesics, adequate hydration, antiemetics, treat concurrent
relapse prevention

25
non-pharmacological management of relapse prevention
CBT motivational enhancement therapy 12 step facilitation programme self-control training
26
pharmacological management of relapse prevention for alcohol
avoid BZDs antabuse (disulfram) acamprosate naltrexone (FIRST LINE)
27
what pathway mediates a natural or drug induced high?
mesolimbic pathway
28
physical risks around substance misuse
skin infections BBV endocarditis/ embolic events tract damage
29
psychiatric risks around substance misuse
``` dependence seizures delirium anxiety depression psychosis ```
30
social risks around substance misuse
employment driving debt criminal activity
31
phases of treatment
induction optimisation maintenance reduction
32
options for opiate withdrawal
methadone | buprenorphine
33
action of methadone
Mu receptor agonist peaks at 4 hour steady state 5 days hepatic metabolism CY3P4
34
action of buprenorphine
Mu receptor partial agonists peak 1.5-2.5 hours sublingual tablets community pharmacists under supervision
35
when is methadone not first line/ avoided?
prolongs QT so avoid in cardiovascular disease methadone causes sedation polypharmacy diversion risk