Acute Kidney Injury Flashcards
Acute kidney injury is defined as being an increase in serum creatinine by how much AND urine volume of how much?
Increase in serum creatinine: by ≥ 26.5 μmol/l (0.3 mg/dl ) within 48 hours
or
to ≥ 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days
AND
Urine volume <0.5ml/kg for 6hrs
What are some of the immediately dangerous consequences of AKI?
Acidosis
Electrolyte imbalance
Intoxication
Overload
Uraemic complications
AEIOU
For AKI Stage 1, what is the serum creatinine level?
1.5-1.9 x the baseline
For AKI Stage 1, what is the urine output?
<0.5ml/kg/h for 6-12hrs
For AKI Stage 2, what is the serum creatinine level?
2-2.0 x the baseline
For AKI Stage 2, what is the urine output?
<0.5ml/lg/h for >12hrs
For AKI Stage 3, what is the serum creatinine level?
3 x the baseline
What are some of the pre-renal causes of AKI?
Cardiac failure
Haemorrhage
Sepsis
Vomiting and diarrhoea
What are some of the intrinsic causes of AKI?
Glomerulonephritis
Vasculitis
Radiocontrast
Myeloma
Rhabdomyolysis
Drugs e.g. NSAIDs, gentamicin
What are some post-renal (obstruction) cause of AKI?
Tumours
Prostate disease
Stones
What are some risk factors for AKI?
Age >75
Previous AKI
Heart failure
Liver disease
CKD
Diabetes
Vascular disease
Cognitive impairment
What are some risk events for AKI?
Sepsis
Toxins
Hypotension
Hypovolaemia
Major surgery
List some toxins which should be avoided if a patient is at risk of AKI.
Gentamicin
NSAIDs
IV iodinated contrast
There are some medications which should not be taken if someone has vomiting or diarrhoea, fevers, sweats and shaking.
They can be restarted when the individual is well.
Give some examples of these medicines.
ACEi
ARBs
NSAIDs
Diuretics
Metformin
Give some examples of ACEi
Ramipril, lisinopril