Acute Inflammation Pt. 1

Question 1

Which part of TLR-4 binds LPS

Answer 1

CD14

Question 2

What is the key intracellular regulator in innate immunity

Answer 2

NF-kB

Question 3

Vasodilation in inflammation occurs where

Answer 3

arteriole

Question 4

Increased vascular permeability in inflammation occurs where

Answer 4

post-capillary venule

Question 5

Which leukotriene attracts neutrophils

Answer 5

LTB4

Question 6

What causes mast cell degranulation

Answer 6

antigen binding surface receptor IgE
IgE is surface bound in mast cells
mast cells degranulate in response to antigen binding the cell surface IgE receptors

Question 7

Classical complement pathway activated by

Answer 7

IgM and IgG

Question 8

Alternative complement pathway activated by

Answer 8

microbial products

Question 9

MBL complement pathway activated by

Answer 9

MBL binds mannose on microorganisms to activate complement

Question 10

How does Factor XII/Hageman factor cause DIC

Answer 10

activated in Gram - sepsis

Question 11

Mechanism of fever

Answer 11

IL-1 and TNF released from macrophages
IL-1 and TNF cause release of IL-1 from perivascular cells in hypothalamus
hypothalamus resets basal temp set point