Acute Inflammation Flashcards
What are the main clinical symptoms of inflammation
Heat loss
Redness
Swelling
Pain
What is starlings law
The movement of fluid would depend on oncotic and hydrostatic pressure
What would occur if the oncotic pressure was higher on the outside of the vessel
The fluid would move outwards down the concentration gradient
What the extrudate fluid
The fluid that would move out as a result of inflammation.
What is transudate fluid
Fluid that would leave the capillary’s as a result of the high hydrostatic pressure
This would be caused through the renal and hepatic and heart failure (alter the pressures and also alter the amount of proteins in the vessels)
What happens to the blood viscosity and flow when fluid leaves
Viscocity increases
Flow decreases (stasis)
What are the main cells of inflammation
Neutrophils
What are the mechanisms that increase vascular permeability
Rearrangement of the cytoskeleton
Gaps in the capillary’s
Injury by toxic burns
What is a leukocyte
Blood cells produced in the bone marrow and travel to the lymph nodes and the body
What are the 2 proteins that would help with cell adhesions
Selectins: on the surface of the endothelium membrane
Intergins: on the surface of the the neutrophils
What are the chemotaxis
Would attach the phagocytes to the site of inflammation
Move them by chemical gradients
What are the steps of neutrophils infiltration
Margination: line up of the margin of the surface
Rolling: roll along the surface and would attach
Adhesion: the selectins and the intergins would attach to each other
Emigration: would move into the vessel
Why is pain important for inflammation
Would allow rest to occur
How does odema (accumulation of fluid limit damage)
Dilutes the toxins
Increased lymphatic drainage
Delivers plasma proteins to the site of the inflammation
What do the cytokines do in the blood vessels
Would allow the blood vessels to become more leaky and so would allow the vasodilation
This would then allow the fluid to move out the vessels
