AB List

Question 1

PCN G (IV)
PCN V (oral)

Answer 1

MOA: bind to PBP, inhibit cell wall synthesis

USE: Gram + / Syphilis

AE: Hypersensitivity rxn / GI (dia, c diff)

Question 2

Nafcillin (IV)
Dicloxacillin (oral)
Oxacillin (IV)
Amoxicillin (oral) (+ CA)
Ampicillin (oral or IV)
Piperacillin + tazobactam (IV)

Answer 2

MOA: bind to PBP, inhibit cell wall synthesis

USE: Gram + (only AAPT: also Gram -)

AE: Hypersensitivity rxn / GI (dia, c diff)

Question 3

Cephalexin (oral) 1
Cefazolin (IV) 1
Cefuroxime (oral, IV, or IM) 2
Cefoxitin (IV or IM) 2
Cefotetan (IV or IM) 2
Ceftazidime (IV) 3
Ceftriaxone (IV) 3
Cefepime (IV) 4
Ceftaroline (IV) 0

All Cephalosporins

Answer 3

MOA: Similar to penicillins but more resistant to inactivation by many β-lactamases

USE: Gram + and -

AE:
-Hypersensitivity reactions
-Diarrhea, C. difficile infections

All cephalosporins require dose adjustment for low kidney function (except ceftriaxone)

Ceftaroline: Only β-lactam antibiotic with activity against MRSA

Question 4

Aztreonam

Answer 4

MOA: similar to penicillins but more resistant to inactivation by many β-lactamases (broad spec)

USE: ONLY GRAM -

Cross-reactivity with ceftazidime allergy

AZ is an NPC

Question 5

Meropenem (carbapenem)

Answer 5

MOA: similar to penicillins but more resistant to inactivation by many β-lactamases (broad spec)

USE: Gram + and - : broad spec

Serious or highly resistant hospital infections

Question 6

Vancomycin

Answer 6

MOA: blocks crosslinking of peptidoglycan, inhibit cell wall synthesis

USE: GRAM + ONLY (yes MRSA)

AE: flushing syndrome, nephrotox, ototox

PC FNO (pc? fuck no)

Question 7

Daptomycin

Answer 7

MOA: binds plasma membrane and causes depolarization with metabolite leakage

USE: GRAM + ONLY

DO NOT use for pneumonia

AE: myopathy, muscle weakness

PPP MM

Question 8

Gentamicin - Aminoglycoside

Answer 8

MOA: inhibit by binding to 30S R subunit

USE: GRAM -

AE: oto, néphron, nm blockade

Jenna is 30 and NEGative and NONe fun

Question 9

Doxycycline

Answer 9

MOA: inhibit by binding to 30S R subunit

USE: broad spectrum

AE: photosensitive, GI (NVD), bone and teeth problems

DOXY is 30 and full of BS, a PG Bitch

Question 10

Tigecycline

Answer 10

MOA: inhibit by binding to 30S R subunit

USE: broad spectrum

TI is 30 and full of BS

Question 11

Azithromycin (MACRO)

Answer 11

MOA: Reversibly bind to 50S subunit of R

USE: broad spectrum

AE: GI (NVD), LQTS = CA

Question 12

Clindamycin

Answer 12

MOA: Reversibly bind to 50S subunit of R

USE: GRAM + , anaerobe above dia

AE: GI (NV), cause C diff

Question 13

Linezolid

Answer 13

MOA: Reversibly bind to 50S subunit of R

USE: GRAM + ONLY

AE: GI (NVD), MAOI activity (serotonin syndrome when used with SSRIs)

Question 14

Ciprofloxacin
Levofloxacin
Moxifloxacin

Answer 14

MOA: inhibit DNA synthesis

USE: broad spec

AE: LQTS, arthropathy, C DIFF, cartilage damage

Contraindicated in pregnancy and children < 18 years old

Question 15

Metronidazole

Answer 15

MOA: inhibit DNA synthesis

USE: below dia, C DIFF, Protoza

AE: NV with alc, metallic taste

AVOID in preg (mutagenic)

Question 16

Sulfamethoxazole + Trimethoprim

Answer 16

MOA: inhibit DNA synthesis and folate synthesis

USE: broad spec

AE: Stevens-Johnson Syndrome (rash, high K)

Dose adjustments needed in patients with kidney function; CI severe renal prob

Question 17

Rifampin

Answer 17

MOA: inhibition of RNA synthesis

USE: GRAM + / TB / leprosy