9- PTM Flashcards
1
Q
Bromodomain (BRD)
A
Protein domain capable of recognizing an acetylated lysine
43 reader proteins have bromodomains
Acts as a platform to recruit other proteins to create complexes
Proteins can have up to 6 bromodomains
2
Q
Monoubiquitination
A
Signaling/endocytosis
Gene expression
Protein interactions
3
Q
Multiubiquitination
A
Endocytosis
4
Q
Polyubiquitination
A
Proteasomal degradation
5
Q
Common neurological disorders associated with E3 ligase genetic variations
A
SCZ
Intellectual disability
Autism spectrum disorder
Tourettes
6
Q
Symptoms of Angelman Syndrome
A
Severe developmental delay
Balance disorder
Atypical laughter/smiling
Life expectancy is normal
7
Q
Taupathies
A
Group of neurodegenerative disorders characterized by the deposition of abnormal tau proteins in the brain
