3-Pre/Post-Synaptic Terminals

Question 1

RIMS

Answer 1

Has several protein binding domains (brings them together)

Question 2

RIM-BP

Answer 2

Recruits Ca- channel to active zone

Intermediate between RIM and Ca channel

Question 3

MUNC13

Answer 3

Brings vesicles close to docking site

Question 4

ELKs

Answer 4

Not always essnetial

Probably synapse specific. involved in fine tuning of organization

Question 5

Piccolo/Bassoon

Answer 5

Larger role in periphery

Role still unclear (involved in organization somehow)

Question 6

Α-Liprin

Answer 6

Defines size of active zone (restricts it so can focus necessary proteins)

Interacts with cell adhesion molecules

Question 7

Snap 25

Answer 7

Also interacts with vesicle

Question 8

Complexin

Answer 8

Fixes complex into superprime state (have wedge in between vesicle and PM), need force to remove

Question 9

Active Zone

Answer 9

Located in pre synaptic density

Found exactly opposite to pre-synaptic specialization

Question 10

Neurexins and Brain Disorders

Answer 10

Heterozygous deletions of neurexin genes can cause autism, SCZ, intellectual disability

Due to elimination of exons in neurexin-1-gene

Question 11

Terminal Deletion

Answer 11

Loss of one end of chromosome

Question 12

Interstitial Deletion

Answer 12

Middle Segment Lost

Question 13

Neurexin

Answer 13

Cells surface proteins with more than 1000 proteins

Question 14

Kiss and Run

Answer 14

Vesicle releases all NT and leaves active zone without fully fusing with membrane

Doesn’t need clathrin

Reacidifies and refills

Question 15

Kiss and Stay

Answer 15

Doesn’t release all NT

Doesn’t need active zone