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NEUR 3100 > 5- Glutamate > Flashcards

5- Glutamate Flashcards

1
Q

VGLUT1/2

A

Glutamate

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2
Q

VGLUT3

A

GABA
ACh
Monoamines

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3
Q

EAAT1/2

A

In glial cell membrane

EAAT 2 responsible for over 90% of GLUT reuptake in CNS

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4
Q

EAAT3/4

A

Exclusively neuronal

In axon terminals, cell bodies, dendrites

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5
Q

EAAT5

A

Only found in retina (photoreceptors, bipolar neurons)

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6
Q

Cyclothiazide

A

PAM

Prevents AMPAR desensitization withous affecting other GLURs

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7
Q

NBQX

A

Selective antagonist of AMPARs

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8
Q

LTP

A

Long lasting increases in synaptic response following high frequency stimulation

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9
Q

Concanavalin A

A

Prevents KARs desensitization without affecting AMPARs

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10
Q

CNQX

A

Competitive antagonist of KARs and AMPARs

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11
Q

NMDAR Binding Sites

A

GLUT (agonist)
Glycine (agonist)

H+ (inhibitory)
Mg (inhibitory)
Zn (inhibitory)

Polyamine modulator site (Spermine)

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12
Q

MK-801

A

Voltage dependent antagonist

Non-reversible block

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13
Q

Ketamine

A

Voltage dependent antagonist

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14
Q

PCP

A

Voltage dependent antagonist

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15
Q

Memantine

A

Voltage dependent antagonist

Low affinity

Used to treat moderate to severe AD

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16
Q

D-APS

A

Antagonist at GLUT binding site

Voltage dependent antagonist

17
Q

D-serine

A

Endogenous agonist at glycine site

18
Q

Thrombus

A

Aggregated platelets and` RCB clumped together by fibrin

19
Q

M1,5 Agonist

A

DHPG

20
Q

M2,3 Agonist

A

APDC

21
Q

M4. 6-8 Agonist

A

I-AP4

22
Q

Full KO

A

Gene disrupted in all cells

23
Q

Condition Gene KO

A

Only have KO in certain region (i.e. HPC)

Relies on promoter of gene that is only found in a specific tissue/cell

24
Q

Inducible Gene KO

A

Administer drug to activate genomic changes

25
Q

mGluR and Umami

A

mGluR1, 4 responsible for umamai

Found in all regions of tongue bearing taste buds

Low humidity and pressure in airplanes affects taste receptors, but not umami ones

Foods with high level of GLU like tomatoes become even more savory

NEUR 3100 (10 decks)

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