5- Glutamate Flashcards
VGLUT1/2
Glutamate
VGLUT3
GABA
ACh
Monoamines
EAAT1/2
In glial cell membrane
EAAT 2 responsible for over 90% of GLUT reuptake in CNS
EAAT3/4
Exclusively neuronal
In axon terminals, cell bodies, dendrites
EAAT5
Only found in retina (photoreceptors, bipolar neurons)
Cyclothiazide
PAM
Prevents AMPAR desensitization withous affecting other GLURs
NBQX
Selective antagonist of AMPARs
LTP
Long lasting increases in synaptic response following high frequency stimulation
Concanavalin A
Prevents KARs desensitization without affecting AMPARs
CNQX
Competitive antagonist of KARs and AMPARs
NMDAR Binding Sites
GLUT (agonist)
Glycine (agonist)
H+ (inhibitory)
Mg (inhibitory)
Zn (inhibitory)
Polyamine modulator site (Spermine)
MK-801
Voltage dependent antagonist
Non-reversible block
Ketamine
Voltage dependent antagonist
PCP
Voltage dependent antagonist
Memantine
Voltage dependent antagonist
Low affinity
Used to treat moderate to severe AD
D-APS
Antagonist at GLUT binding site
Voltage dependent antagonist
D-serine
Endogenous agonist at glycine site
Thrombus
Aggregated platelets and` RCB clumped together by fibrin
M1,5 Agonist
DHPG
M2,3 Agonist
APDC
M4. 6-8 Agonist
I-AP4
Full KO
Gene disrupted in all cells
Condition Gene KO
Only have KO in certain region (i.e. HPC)
Relies on promoter of gene that is only found in a specific tissue/cell
Inducible Gene KO
Administer drug to activate genomic changes
mGluR and Umami
mGluR1, 4 responsible for umamai
Found in all regions of tongue bearing taste buds
Low humidity and pressure in airplanes affects taste receptors, but not umami ones
Foods with high level of GLU like tomatoes become even more savory
