4- Catecholamines

Question 1

Cocaine

Answer 1

Binds directly to DAT (high affinity)

Inhibits reuptake of DA, NE, 5-HT

Question 2

Methylphenidate

Answer 2

Inhibits DAT

Used to treat ADHD and narcolepsy (affects sleep and wake)

Produces 3-4x increase in DA and NE in striatum and PFC

Question 3

Common Side Effects of Methylphenidate

Answer 3

Nervousness
Agitation
Insomnia
Anxiety
Loss of Appeptite

Question 4

Ritalin vs. Cocaine

Answer 4

Ritalin has much lower affinity for DAT- slower response= less addictive

But at high doses Ritalin can have similar effects as cocaine

Question 5

MAO-A

Answer 5

Breaks down all monoamines

Question 6

MAO-B

Answer 6

Only breaks down DA

Question 7

Fenfluramine

Answer 7

Appetite suppresant

Blocks both VMAT 2 and SERT

Question 8

MDMA

Answer 8

Ecstasy

Blocks both VMAT 2 and SERt

Also reverses flow of SERT (increases release)

Question 9

Chlorpromazine

Answer 9

First effective antipsychotic for treatment of SCA

Question 10

Imipramine

Answer 10

Discovered during search for SCZ treatment

Found to improve severe depression, not psychosis

First TCA

Inhibitor of NE and 5-HT reuptake

Question 11

Sumatriptan

Answer 11

Anti-migraine

Targets 5-HT

Question 12

LSD

Answer 12

Targets 5-HT

Hallucinogenic drug

Question 13

Ondansetron

Answer 13

Targets 5-HT

Anti-emetic

Question 14

MAOi

Answer 14

Treatment of depression