9: Prion Flashcards
1
Q
What are the three types of prion disease?
A
Acquired, genetic or sporadic
2
Q
What mutation gives genetic prion disease?
A
Mutation in ORF of PrP gene
3
Q
What is susceptibility of mice devoid of PrPC like?
A
Resistant
4
Q
In which cells is PrPC expressed?
A
Neurones and follicular dendritic cells
5
Q
What type of protein is PrPC?
A
GPI-linked, copper-binding
6
Q
What is PrPC like in its mature form?
A
Diglycosylated
7
Q
What are the properties of PrPSc?
A
B sheet, oligomeric, detergent-insoluble, resistant to proteinase K
8
Q
How common are single PrPSc moecules?
A
Don’t exist
9
Q
What is the core unit of PrPSc?
A
Trimer
