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pharma B.DAM > 9. norepinephrine and serotonin receptor antagonist antidepressants. Agomelatine. Tianeptine. Agents used for treatment of manic phase of bipolar disorders > Flashcards

9. norepinephrine and serotonin receptor antagonist antidepressants. Agomelatine. Tianeptine. Agents used for treatment of manic phase of bipolar disorders Flashcards

1
Q

Norepinephrine and serotonin receptor antagonist antidepressants

A

that are selective Serotonin reuptake inhibitors that have direct antagonistic effect on restorers and and 5-HT2(3) antagonist and NE reuptake inhibitor

that are NE reuptake inhibitors & α2 and 5-HT2, (3) antagonist

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2
Q

Serotonin reuptake inhibitors & 5-HT2A antagonists

A

AE: hepatotoxic, very sedative
Moderate α1 receptor antagonism

drugs …
Trazodone
Nefazodone

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3
Q

Serotonin reuptake inhibitors & 5-HT1A partial agonist

A

Vilazodone

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4
Q

Serotonin reuptake inhibitors & 5-HT3A , 5-HT7 antagonist, 5-HT1A,B partial agonis

A

Vortioxetine

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5
Q

NE reuptake inhibitors α2 and 5-HT2, (3) antagonist

A

Mirtazapine

Mianserine

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6
Q

Agomelatine

A

Melatonin (MT1 MT2) agonist
5-HT2C inhibition
recovery of circadian rythem
incraes sexual function & sleep

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7
Q

Tianeptine

A

Enhances of 5-HT reuptake

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8
Q

treatment of manic phase of bipolar disorders

A

Lithium carbonate
Anticonvulsant agents
Ca++ channel blockers
some Antipsychotics

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9
Q

Trazodone

A

Serotonin reuptake inhibitors & 5-HT2A antagonists

used for insomnia as well

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10
Q

Mirtazapine

A

NE reuptake inhibitors & α2 and 5-HT2, (3) antagonist

highly sedative

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11
Q

Anticonvulsant agents

A

Carbamazepine
Valproate
Clonazepam

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12
Q

Ca++ channel blockers

A

Verapamil

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13
Q

in what situation using Antipsychotics in bipolar

A

acute phase & mood stabilizer

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14
Q

Antipsychotics for acute phase

A

Haloperidol

Clozapine

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15
Q

Antipsychotics for mood stabilizer

A 
Olanzapine
Quetiapine
Risperidone
Aripiprazole
Ziprasidone
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16
Q

Lithium carbonate

A 
used for Acute & prophylactic managing of bipolar patients 
Low TI 
half-life ~20hr 
complete GI absorption 
No metabolism

pharma B.DAM (12 decks)

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