12. Drugs used for treatment of neurodegenerative disorders. Nootropic drugs Flashcards
neurodegenerative disorders
Parkinson’s disease Alzheimer’s disease multiple sclerosis amyotrophic lateral sclerosis (ALS) Wilson’s disease dementias Huntington disease
drugs for Parkinson’s disease
Dopamine precursors Dopamine receptor agonists Dopamine turnover enhancer MAO inhibitors COMT inhibitors Antimuscarinic agents
drugs for Alzheimer’s disease
Centrally acting acetylcholinesterase inhibitors
NMDA receptor antagonists
Antioxidants
drugs for multiple sclerosis
Interferon β1a and β1b
drugs for amyotrophic lateral sclerosis (ALS)
Riluzole
drugs for Wilson’s disease
Penicillamine
drugs for dementias
Nootropic drugs Antioxidants Calcium antagonists NSAIDs Estrogens
drugs for Huntington disease
Tetrabenazine
Dopamine precursors
Levodopa
Levodopa
Good Gi absorption & goes threw BBB
AE: GI + cardiovascular, in CNS: mood, hallucinations and movement.
Carbidopa
Given with levodopa
peripheral DOPA decarboxylase inhibitor
Pyridoxine
Vit. B6
increases decarboxylase activity
MAO inhibitors used in Parkinson
Selegiline
Rasagiline
Selegiline
used in Parkinson & depression & Alzheimer’s disease
ireversible MAO-B
Rasagiline
used in Parkinson
irreversible and selective inhibitor of brain MAO-B
rasagiline is not metabolized to an amphetamine-like substance
COMT inhibitors
selectively and reversibly inhibit COMT
inhibits consumption of levodopa
drugs…
Entacapone
Tolcapone