7. Tricyclic, tetracyclic and unicyclic antidepressants. MAO-inhibitors Flashcards
Tricyclic antidepressants
inhibits NE and 5-HT reuptake
secondary choice
Blocking H1 ,α1, M, 5-HT2
narrow TI
drugs ... Amitriptyline Imipramine Trimipramine Desipramine Clomipramine
tetracyclic antidepressants
Maprotiline
Amoxapine
Mirtazapine
unicyclic antidepressants
Bupropion
Amitriptyline
5-HT = NE reuptake
prevent migraine and neuropathic pain
Imipramine
5-HT > NE reuptake
for bed-wetting in children >6 replaced by desmopressin
AE: orthostatic hypotension
Trimipramine
AE: Very marked sedation
Desipramine
Tricyclic antidepressants
NE > 5-HT reuptake
Maprotiline & Amoxapine
tetracyclic antidepressants
NE > 5-HT reuptake
Mirtazapine
no sexual side effect
Bupropion
no sexual side effects
AE: has CNS activating properties
weak DA and NE reuptake inhibitor
smoking cessation
MAO-inhibitors
last line of action in antidepressant
types …
Non-selective irreversible
selective reversible
selective irreversible
Non-selective irreversible MAO-inhibitors
for severe depression
AE: cheese effect
drugs …
Phenelzine
Tranylcypromine
selective reversible MAO-inhibitors
Moclobemide
selective irreversible MAO-inhibitors
Selegiline
Selegiline
used for parkinson’s disease & depression
MAO B inhibitor selective ireversible
minimal chees effect
