4. Non benzodiazepine anxiolytics and non-benzodiazepine hypnotics

Question 1

Cyclopyrrolone or imidazopyridine derivatives

Answer 1

minor effect on sleep patterns
less tolerance and dependence than Benzodiazepines

drugs…
Zaleplon
Zolpidem
Eszopiclone

Question 2

Zaleplon & Zolpidem

Answer 2

selectively acting on BDZ1

Question 3

Non-GABAergic hypnotics

Answer 3

Ramelteon

Question 4

Non-GABAergic anxiolytics

Answer 4

Buspirone

Reuptake inhibitors

Question 5

Barbiturates

Answer 5

act on GABA.A
disadvantages tolerance and physical dependence withdrawal symptoms
induce full surgical anesthesia
AE: low margin of safety !no antidote for barbiturates

types …
Long acting
Medium and short-acting
Ultra-short acting

Question 6

Long acting Barbiturates

Answer 6

Phenobarbital

Question 7

Medium and short-acting Barbiturates

Answer 7

Cyclobarbital

Amobarbital

Question 8

Ultra-short acting Barbiturates

Answer 8

IV anesthetics
20 min duration of action
mainly for induction

drugs …
Thiopental
Methohexital

Question 9

Phenobarbital

Answer 9

antiepileptic

Question 10

Cyclobarbital & Amobarbital

Answer 10

short-acting Barbiturates

Hypnotic

Question 11

Ramelteon

Answer 11

Non-GABAergic hypnotics
Selective MT1 and MT2 (melatonin receptors)
for falling asleep
no rebound insomnia

Question 12

Buspirone

Answer 12

Non-GABAergic anxiolytics (5-HT1a)

partial agonist at brain 5-HT1A receptors + some affinity for D2 and 5-HT2A receptors

Question 13

Reuptake inhibitors

Answer 13

Non-GABAergic anxiolytics
for chronic panic attacks
1st line in chronic anxiet
used in depression as well

type
SSRI

Question 14

hypnotics non BZN GABAergic

Answer 14

Cyclopyrrolone or imidazopyridine derivatives
Barbiturates

elderly patients more sensitive to side effect of this