9. Neoplasia II - Invasion and Metastasis

Question 0

What 3 main alterations permit invasion of a neoplasm?

Answer 0

Adhesion
Proteases
Motility

Question 1

What 4 things must a neoplasm do to form at a secondary site?

Answer 1

1 Grow and invade at the primary site
2 Enter a transport system
3 Grow at secondary site (colonisation)
Must avoid destruction from immune cells

Question 2

What are the 3 main transport routes for metastasis?

Answer 2

Blood vessels
Lymphatic vessels
Transcoelomic spread

Question 3

What are the 2 main factors that determine the site of a secondary tumour?

Answer 3

Where the regional drainage of blood vessels, lymph and coelomic fluid is
Seed and soil phenomenon

Question 4

Sarcomas usually use which method of transport?

Answer 4

Blood vessels

Question 5

Carcinomas usually use which method of transport?

Answer 5

Lymphatic system

Question 6

Bronchial small cell carcinoma can release what hormones?

Answer 6

ACTH

ADH

Question 7

Bronchial squamous cell carcinoma can produce what, what does this increase blood levels of?

Answer 7

PTHrp

This leads to hypercalcaemia