9/30/12 Flashcards
What is the first test for primary syphilis?
darkfield microscopy
What is the first test for secondary syphilis?
VDRL
What syndrome is associated with α-L-iduronidase deficiency?
Hurler syndrome
Hexosaminidase-A is the enzyme deficient in _______.
Tay-Sachs disease
What is the effect of Addison’s disease on serum fluid volume and osmolarity? Why?
Water and salt are lost, but ADH helps retain some water. Therefore, serum volume and osmolarity will both decrease.
Anti-microsomal Ab’s are associated with what autoimmune disease?
Hashimoto’s thyroiditis
What dangerous conditrion is associated w/ Ab’s against ADAMTS-13?
TTP
What is ADAMTS-13?
A metalloproteinase that cleaves vWF multimers.
What are the thrombi of TTP made up of?
vWF multimers that combine w/ plt’s
Aside from those mentioned in the name, what are the 2 classic manifestations of TTP?
microangiopathic anemia and neurologic abnormalities
What is Factor V Leiden and what does it cause?
overactive Factor V –> thrombotic tendency
Why is Factor V Leiden overactive?
It can’t be degraded by Protein C.
What is typical in the blood smear of pts w/ TTP?
Schistocytes (microangiopathic destruction d/t thrombotic occlusions) and, of course, plt-penia.
What are the 2 main effects of ACE-I’s on serum electrolytes? What other kind of drug effects are these analogous to?
Na+ loss and K+ retention, like K+-sparing diuretics.
What diuretic would be best at alkalinizing the urine?
acetazolamide
