10/6/12 Flashcards
On what arm of what chromosome is the tumor supressor gene BRCA-1 located?
17q
Which autoimmune disease is associated w/ myocardial fibrosis?
systemic sclerosis
Where is the VHL gene located?
3p
Where is the APC gene located?
5q
What chromosome is the frataxin gene located on?
9
On which chromosome is the DPC (pancreatic cancer) gene located?
18
What do heaves indicate on a cardiac exam?
ventricular hypertrophy
Where would the heave of right ventricular be felt?
left parasternal area
Describe the heave of LV hypertrophy?
sustained apical heave
Palsy of upward gaze, dissociation of light an d accomodation, and failure of convergence indicate compression of the _______.
tectum
What kind of childhood brain tumor would present w/ headache, nausea, vomiting, and papilledema along w/ cerebellar signs such as ataxia, dysarthria, nystagmus, and intention tremor?
astrocytoma of the cerebellum
What is the relationship between pressure, flow, and resistance?
P=QR
What is TPR in terms of CO and MAP?
TPR = MAP/CO
What is the most common means of drug-resistance transfer, esp. among Gram(-) bacilli?
F+ to F- conjugation (plasmid transfer)
What is the means by which S. pneumoniae likely gain PBP mutations?
transformation
What is the means by whic S. aureus is thought to gain methicillin resistance and P. aeruginosa imipenem resistance?
specialized transduction
What are 3 important bacteria capable of natural transformation?
S. pneumoniae, H. influenzae, and Neisseria spp.
What is the most common bacterial STD in America?
Chlamydia trachomatis
What cytokines, released by the Th1 cell, activate the cytotoxic T-cell?
IL-2, IFN-γ, and TNF-β
What kind of hypersensitivity rxn is PID?
type IV
What cytokines, released by Th2 cells, inhibit Th1 cells?
IL-4 and IL-10
What cytokine, released by Th1 cells, inhibit Th2 cells?
IFNγ
Defects in what enzyme could cause hypospadias and poor development of male genitalia?
α-reductase
Drug of choice in uncomplicated Lyme disease?
doxycycline or amoxicillin
