10/5/12 b Flashcards
Metolazide and idapamide belong to what class of diuretic?
thiazide
Pt’s w/ _______ should not be given thiazides (or most diuretics).
sulfonamide allergy
Thiazides and other non-K+-sparing diuretics risk what acid-base disturbance.
alkalosis
The lacunar variant of Reed-Sternberg cells and collagen fibrils are seen in the histopathology of what disease?
nodular, sclerosing Hodgkin’s lymphoma
In what syndrome do you see esophageal webs?
Plummer-Vinson syndrome
What is the main Sx of esophageal webs?
selective dysphagia
What are the 3 components of Plummer-Vinson syndrome?
atrophic glossitis, esophageal webs, Fe_def anemia
What part of the esophagus do esophageal webs usually occur in?
upper 1/3
Pts w/ Plummer-Vinson syndrome are at increased risk of developing what serious disease?
squamous cell carcinoma of the esophagus
How many molecules of ATP are normally made from 1 molecule of glucose in normal ANAEROBIC respiration?
2
How is CNS toxoplasmosis treated?
pyrimethamine and sulfadiazine
What is the classic triad of Wiskott-Aldrich Syndrome?
purpura, eczema, and infections w/ bacteria w/ polysaccharide capsules
What are the immunoglobulin levels of Wiskpott-Aldrich syndrome?
low IgM, normal IgG, high IgA/IgE
What immunodeficiency shows up later in life in Wiskott-Aldrich Syndrome?
T-cell deficiency
What immune deficit characterizes cmmon variable immunodeficiency?
humoral deficiency
When does common variable immunodeficiency usu. appear?
late teens/early twenties
What is the inheritance pattern of Wiskott-Aldrich?
XR
What cardiovascular anomaly, other than coarctation of the aorta, is commonly found in women w/ Turner syndrome?
bicuspid aortic valve
Autonomic control of vascular tone is entirely controlled by the _______ nervous system.
sympathetic
Which CN is stimulated by stretch of the carotid bodies?
CN IX (glossopharyngeal)
Which CN is stimulated by the stretch of the aortic baroreceptors?
CN X (vagus)
Within what period of time may thrombolytics be administered to the victim of an ischemic stroke?
3 hrs
Why is the effect of alteplase limited to the site of thrombotic occlusion?
plasminogen is activated better in the presence of fibrin
What is selegeline?
a centrally-acting MAO-I used in Parkinson’s
What is the mechanism of action of acyclovir?
gaunosine analog - terminates DNA replication
What bone disease is associated w/ celiac sprue?
osteoporosis
Ova in the ovaries are arrested in which stage of meosis?
Diplotene stage of Prophase I