10/1/12 Flashcards
What is the mech of malathion and other organophosphates?
irreversible inhibition of cholinesterase
What other major effect do first generation H1 antagonists have that leads to many of their side effects?
anticholinergic
A pt has mydriasis, palpitations, and muscle weakness. Which symptom would indicate that this is d/t botulinum toxin and not atropine?
muscle weakness (nicotinic receptors!)
What autoimmune disease is anti-glutamic acid decarboxylase seen in?
DM I
What is the mech of acarbose in DM 2 tx?
alpha-glucosidase inhibitor - inhibits pancreatic and intestinal enzymes to slow the absorption of glucose
What vitamin should be supplemented during phototherapy for neonatal jaundice, as it is also degraded by sunlight?
Riboflavin
Where does unconjugated bilirubin accumulate to cause neurological problems in kernicterus?
basal ganglia
What are the only cells capable of killing infected RBCs?
NK
What is the most specific cell surface marker for NK cells?
CD-56
Multiple sclerosis is classified as a _______ hypersensitivity disease.
type IV
What hepatits virus has a special propensity for infecting pregnant women?
HEV
What viral family does HEV belong to?
HepEviridae
What testicular cancer consists of nests of cells w/ conspicuous nucleoli and clear cytoplasm - nests surrounded by thin, fibrous septae?
seminoma
Seminomas are classically express what marker?
placental alkaline phosphatase (PLAP)
What two types of cells make up a seminoma?
neoplastic cells and lymphocytes
