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Immunosero Lec (Midterm) > 8.1 Transplantation immunology > Flashcards

8.1 Transplantation immunology Flashcards

1
Q

A life saving procedure for end stage organ failure, malignancies, autoimmune, and etc.

A process in which a recipient receives cells or tissues from a donor

A

Transplantation

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2
Q

Transplants (Grafts) are classified according to genetic disparity between the donor and the recipient (MHC)

T or F

A

T

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3
Q

Type of graft that tissues from one area to another from the same individual

A

Autograft

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4
Q

Type of graft that tissue from identical twins

A

Syngeneic graft

Syngraft

Isograft

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5
Q

Type of graft that tissues from different individuals in the same species

A

Allograft

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6
Q

Type of graft that tissues from different species

A

Xenograft

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7
Q

Type of allograft rejection that occurs within minutes to hours after vascular supply to the graft has been established

A

Hyperacute

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8
Q

Anti-HLA antibodies is used in hyperacute allograft rejection?

T or F

A

T

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9
Q

Recipient has been previously exposed to donor MHC antigens which is the reasons fro hyperacute allograft rejection

T or F

A

T

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10
Q

Treatment for hyperacute allograft rejection?

A

Graft removal

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11
Q

Type of allograft rejection that occurs weeks after engraftment

A

Acute

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12
Q

Acute allograft rejection are caused by?

A

CD4+ and CD8+ T cell activation

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13
Q

A type of allograft rejection that leads to vigorous immune responses

A

Acute

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14
Q

In acute allograft rejection, severity is dependent on number of T cell clones activated

T or F

A

T

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15
Q

Type of allograft rejection that occurs weeks, months, or years post transplantation which is most likely due to delayed type of hypersensitivity

A

Chronic allograft rejection

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16
Q

Treatment for chronic allograft rejection

A

Graft removal

17
Q

In graft vs host disease, B lymphocytes of immunocompetent donor attack the tissues of immunocompromised recipient.

T or F

A

F

T lymphocytes

18
Q

In graft vs host disease, Immune system of the recipient cannot attack the graft with the different magnitude

T or F

A

F

Same magnitude

19
Q

In immunosuppresive therapies, what cell is being targeted?

A

T cells

20
Q

Patients under immunosuppressive therapies are at risk of infection, malignancy and drug-associated toxicity.

T or F

A

T

21
Q

Recipients and potential donors are screened to ensure the best possible genetic match of MHC to minimize the likelihood of rejection

a. Immunosuppressive therapies
b. Serologic typing
c. Histocompatibility screening
d. Mix lymphocyte reaction

A

c

22
Q

Determination of compatibility by the difference in MHC

A

Tissue cross-matching

23
Q

Considered the method of choice until the development of molecular approaches.

a. Immunosuppressive therapies
b. Serologic typing
c. Histocompatibility screening
d. Mix lymphocyte reaction

A

b

24
Q

The disadvantage of serologic typing is allelic differences can only be detected if an antibody is available for the allele

T or F

A

T

25
Q

In vitro test used to mimic in vivo conditions of transplantation

a. Immunosuppressive therapies
b. Serologic typing
c. Histocompatibility screening
d. Mix lymphocyte reaction

A

d

26
Q

In mixed lymphocyte reaction, th amount of proliferation is equal to the magnitude of rejection

T or F

A

T

27
Q

Limited to living donors only (TAT is several days).

a. Immunosuppressive therapies
b. Serologic typing
c. Histocompatibility screening
d. Mix lymphocyte reaction

A

d

28
Q

DNA is cleaved by enzymes to obtain pattern of fragmentation

Degree of disparity is assessed by comparing patterns of fragmentation.

a. PCR
b. RFLP analysis

A

b

29
Q

Direct amplification of a particular DNA sequence selected by the use of primers that isolates the gene of interest.
a. PCR
b. RFLP analysis

A

a

30
Q

Degree of disparity is assessed by comparing the selected sequences.

a. PCR
b. RFLP analysis

A

a

31
Q

May not be able to predict severity of rejection.

a. PCR
b. RFLP analysis

A

a

32
Q

Do not have the time constraint of MLR and is superior to serological approaches

a. PCR
b. RFLP analysis

A

a

Immunosero Lec (Midterm) (10 decks)

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