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Immunosero Lec (Midterm) > 6.1 Immunoproliferative disorders > Flashcards

6.1 Immunoproliferative disorders Flashcards

1
Q

Increased production of a single class f antibodies by a single clone of lymphoic plasma cells

A

Monoclonal gammopathy

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2
Q

Excessive production of gammaglobulins

A

Hyper gammaglobulinemia

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3
Q

Elevation of two or more antibody types of Several clones of plasma cells; secondary disease

A

Polyclonal gammopathy

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4
Q

Suppresed uninvoled antibodies and dysfunctional T cell response; can be benign or malignant

A

Monoclonal gammopathy

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5
Q

What immunoglobulin is mostly involved in multiple myeloma?

A

IgG

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6
Q

What immunoglobulin is mostly involved in Waldenstrom macroglobulinemia?

A

IgM

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7
Q

Plamsa cell neuplasma; accumlation of malignant plasma in the BM

Normal = 1% plasma cells
Abnormal = 90% plasma cells

A

Mulitple myeloma

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8
Q

Most important test for multiple myeloma

A

Bone marrow aspirate exam / Biopsy

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9
Q

Immature cells with appearance of a plasmablast characterized by cytoplasmic immunoglobulins

A

Myeloma cells

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10
Q

The higher the number of myeloma cells = severerity

T or F

A

T

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11
Q

Lab diag:

Bone marrow exam
CBC
Renal function tests
Urinalysis

What is the disease being diagnose by this test?

A

Multiple myeloma

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12
Q

Why CBC in multiple myeloma being diagnose by it?

A

Anemia

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13
Q

Why Renal function tests in multiple myeloma being diagnose by it?

A

Low Glomeruluous filtration rate

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14
Q

Bence-Jones vs Albumin differentiation test?

A

Heat solubility test

Bence jones = 60C (Coagulate), 100C (dissolve)

Albumin = 60C, 100C (Coagulate)

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15
Q

Hypercalcemia can be caused by multiple myeloma?

T or F

A

T

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16
Q

Eitology of multiple myeloma?

A

Unknown

17
Q

B cell disorder (Malignant lymphocyte-plasma cells)

Characterized by infiltration of lymphplasmacytic cells in BM and presence of IgM monoclonal gammopathy

A

Waldenstrom’s Macroglobulinemia

18
Q

Serum protein electrophoresis
Demonstration of hyperviscous
Presence of cryoglobulins and pyroglobulins

A

Waldenstroms Macroglobulinemia

19
Q

Represents presence of monolonal proteins with no feature of multiple myeloma or related malignant disorder

A

Monoclonal Gammopathy of undetermined significance

20
Q

Secondary manifestation of infection or inflammation

Broad peak on electrophoresis

OOnly one antibody class is elevated but polyclonal in origin

A

Polyclonal gammopathy

Immunosero Lec (Midterm) (10 decks)

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