7.1 Tumor immunoassay Flashcards
Study of antigens associated with tumors,
the tumor’s effect in the immune status, and the use of immune system to eliminate the tumor
Tumor immunology
Regulatory proteins that promote cell division
Protooncogenes
Mutated or altered cell division resulting resulting to uncontrol
Oncogene
Gene that removes growth inhibitor signals when altered or mutated
Tumor suppressor genes
Abnormal cell growths that can be benign or malignant
Tumor or neoplasm
Encapsulated, movable and easily removed type of tumor without causing death
Benign tumor
A type of tumor that grows rapidly by infiltration or expansion, difficult to remove and usually caused death
Malignant tumor
Malignant tumor is encapsulated
T or F
F
Nonencapsulated
When malignant cells travel throguh the body and causes new foci of malignancy until body function is disrupted
Metastasis
Antigen that is specific to a tumor
Tumor-specific-antigen
Antigen seen in tumors cells and limited number of normal cells
Tumor-associated antigens
Potential mechanisms of de novo expression of tumor-specific antigens:
Activation of silent gene resulting to expression of new protein
T or F
T
Potential mechanisms of de novo expression of tumor-specific antigens:
Point mutations that give rise to mutant peptides
T or F
T
Potential mechanisms of de novo expression of tumor-specific antigens:
Alteration in the structure of proteins that does not allow exposure of previously sequestered antigens
T or F
F
Allows exposure
May indicate aberrant expression of proteins that were expressed during
development but not expressed on normal mature cells
Tumor-associated antigens
Antigens during development which expressed in different types of tumors and in normal cells during inflammatory states
Oncofetal antigen
Low concentration of Oncofetal antigen in normal adults
T or F
T
