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Immunosero Lec (Midterm) > 4.1 Autoimmune diseases > Flashcards

4.1 Autoimmune diseases Flashcards

1
Q

These are diseases in which the immune response is targeted towards self-antigens and result in damage to organs and tissues to the body.

A

Autoimmune diseases

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2
Q

Autoimmune diseases are caused by B cells mediated immune response or auto-antibodies

T or F

A

F

T cell

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3
Q

Cure or no cure?

A

No cure

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4
Q

Type of self tolerance that

Occurs in primary lymphoid organs

T cell Test development such as negative selection, Self reactive CD4+

B cells test is included (Seld reactive B cells) for receptor editing

A

Central tolerance

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5
Q

Type of self tolerance that

Result from anerhy due to absence of co-stimulatory signals from APCs

Inhibition of T regulatory cells

Death apoptosis

Secondary lymphoid organ (or body)

A

Peripheral tolerance

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6
Q

Development of specific state of unresponseveness to a specific antigen among weakly slf-reactive B cells

A

Anergy

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7
Q

Theories in AID Initiation:

Altered or changed lymphocyte clone arise as a result of mutation

A

Forbidden clone theory

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8
Q

Theories in AID Initiation:

Self antigens that were changed by physical, chemical, or biological means resulting in a new foreign antigen

A

Altered antigen theory

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9
Q

Theories in AID Initiation:

Exposed “hidden” antigens as a result of trauma or infection

A

Sequestered antigen theory

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10
Q

Theories in AID Initiation:

Loss of deficency of immune regulation

A

Immunologic deficiency theory

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11
Q

Theories in AID Initiation:

froeign antigens having similar epitopes with a self antigens

A

Cross-reactive antigen theory

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12
Q

Generalized disorder of unknown origin that manifest as vasculitis

A

Systemic lupus Erythematosus (SLE)

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13
Q

SLE is associated with HLA-A2, HLA-B8, HLA-DR1

T or F

A

F

HLA-A1, HLA-B8, HLA-DR3

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14
Q

Autoantibody that is not specific for SLE and attacks nuclear antigens?

A

Anti-nuclear antibody(ANA)

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15
Q

What autoantibody (ANA) is specific for SLE?

A

Anti-dsDNA

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16
Q

Butterfly rash is a commonsymptoms for what disease?

A

SLE

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17
Q

Most common cause of mortality in SLE

A

Nephritis

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18
Q

SLE primarily affects Men and has strong hereditary tendency

T or F

A

F

Women

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19
Q

SLE is deadly and not the complications

T or F

A

F

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20
Q

An indirect test that is most widely used and accepted due to its high sensitivity and ability to detect different autoantibodies

A

Fluorescent ANA testing

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21
Q

Patten of Fluorescent ANA test:

Unifroma stainign of the entire nucleus that detects:

dsDNA, histones, and DNP

A

Homogenous/Diffuse

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22
Q

Patten of Fluorescent ANA test:

Greater staining intensity around the outer circle surrounding the nucleus; highly specific for SLE

dsDNA

A

Peripheral/Rim/Outline

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23
Q

Patten of Fluorescent ANA test:

Discrete fluorescent specks throughout the nuclei; no staining on the nucleolus and chromatin region

ENA autoantibodies

A

Speckled

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24
Q

Patten of Fluorescent ANA test:

Prominent staining of the nucleoli within the nucleus

RNA and RNP autoantibodies

A

Nucleolus

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25
Patten of Fluorescent ANA test: Discrete speckles in the nuclei and chromatin of dividing cells Centromere
Centromere
26
EIA/ChLIA, microsphere multiplex immunoassay, and Ouchterlony double diffusion can be used to diagnose for ANA T or F
T
27
Immunofluoresce using S. aureus can be used to diagnose ANA T or F
F Crithidia luciliae
28
Chronic inflammatory disease affecting joints and particular tissues of unknown origin
Rheumatoid arthritis
29
Rheumatoid arthritis can affect heart, lungs and blood vessels T or F
T
30
In rheumatoid arthritis, IgM reacting to the Fc portion of your IgG. Once IgM reacts with IgG, this immune complex will be deposited into your joints T or F
T
31
In RA, Inflammatory changes may lead to loss of function and/or permanent deformity T or F
T
32
atypical amino acid from modification of arginine via peptidyl agrinine deiminase
Citruline
33
Anti-cyclic citrullinated peptide can be found granulocytes, monocytes, macrophages? T or F
T
34
Associated of this disease includes: 1. Wegener’s granulomatosis / granulomatosis with polyangiitis, 2. Microscopic polyangiitis 3. Eosinophilic granulomatosis with polyangiitis
Anti-Neutrophil Cytoplasmic Antibodies
35
formerly known as Churg-Strauss Syndrome
Eosinophili granulomatosis with polyangiitis
36
What are the patterns for anti-neutrophil cytoplasmic antibodies?
c-ANCA (Cytoplasmic) and p-ANCA (Perinuclear)
37
Caused by diffuse granula staining in neutrophil cytoplasm
Cytoplasmic
38
Caused by antibodies against positively charged antigens?
Perinuclear
39
Autoimmune hemolytic anemia: IgG mediated Idiopathic
Warm AIHA
40
Autoimmune hemolytic anemia: IgM mediated Primary atypical pneumonia
Cold AIHA
41
Autoimune hemolytic anemia mediated by a potent cold hemolysin
Paroxysmal cold hemoglobinuria
42
PCH is directed against P antigen T or F
T
43
PCH was demonstrated from what test?
Donath-Landsteiner test
44
in PCH, Biphasic antibody that sensitizes RBCs at ___ and causes hemolysis at ___?
4C 37C
45
Chronic autoimmune thyroiditis that is characterized by intense proliferation of thyroid stroma and follicles by lymphocytes and plasma cells Produces hypothyroidism
Hashimoto's thyroiditis
46
What are the autoantibodies causes Hashimoto's thyroiditis?
Anti-thyroglobulin Anti-thyroid peroxidase
47
Results in the development of germinal centers that almost completely replace normal glandular architecture and progressively destroys the gland
Hashimoto's thyroiditis
48
Diffuse toxic goiter with immunologic origin Produce hyperthyroidism
Grave's disease
49
Grave's disease is caused by?
TSH receptor antibodies (TRAbs)
50
Treatment for Grave's disease is by surgery and radioactive iodine T or F
T
51
Insulin-depenent DM or juvenile onset DM that is caused by Cell-mediated autoimmune destruction of beta cells of the pancreas causing absolute insulinopenia.
Type I deiabetes Mellitus
52
ICA512 IAA GAD65 Tyrosine phosphatase IA-2b This are autoantibodies of Type 1 DM? T or F
T
53
Autoimmune disease that is associated with HLA-DQ2 and DQ8?
Celiac Disease
54
Autoimmune that is associated with gluten that can affect small intestine and other organs
Celicac disease
55
Formely known as chronic active hepatitis that is associated with HLA-DRB1 and HLA-DQB1
Autoimmune hepatitis
56
Anti-smooth muscle Anti-liver kidney microsomal Anti-liver cytosol type 1 Anti-mitochondrial are antibodies of primary biliary cirrhosis T or F
F Autoimmune hepatitis
57
Most common autoimmune liver disease involves progressive destruction of intrahepatic bile duct Asscoiated with HLA-DRB1, DQA1, DPB1, DQB1
Primary biliary cirrhosis
58
Anti-mitochondrial is the only autoantibody for primary biliary cirrhosis? T or F
T
59
A neuromuscular disorder characterized by muscle weakness, fatigue, and the presence of anti-acetylcholine receptor autoantibodies (Anti-AChR)
Myasthenia Gravis
60
A relatively common demyelinating disease involving the white matter of the brain and spinal cord of unknown caused T cell-mediated autoimmune disease
Multiple sclerosis
61
Characterized by abnormal synthesis of IgG in the CNS
Multiple sclerosis
62
Autoantibody against glomerular, renal tubular, and alveolar basement membranes, leading to glomerular injury and rapidly progress to renal failure and pulmonary hemorrhage.
Goodpasture's syndrome
63
Goodpasteur's syndrome Specifically reacts with collagen in the glomerular and alveolar basement membrane T or F
T
64
Goodpasture's syndrome is linked to HLA-DRB1-15 T or F
T
65
Signs and symptoms of goodpasture's syndrome: Glomerular Pulmonary T or F
T

Immunosero Lec (Midterm) (10 decks)

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