8.1 Clot Based Screening tests

Question 1

First laboratory procedure designed to assess coagulation (1913)

Answer 1

Lee and White Whole Blood Coagulation Times

Question 2

Lee and white Whole Blood Coagulation time was used to screen test of all stages of ________ pathway

Answer 2

Intrinsic

Question 3

Principle:Length of time required for a measured amount of venous blood to form a solid clot

Answer 3

Lee and white Whole Blood Coagulation time

Question 4

Measures factors in the EXTRINSIC pathway and COMMON pathway.

Answer 4

Prothrombin time

Question 5

Measures factors in INTRINSIC pathway and COMMON pathway

Answer 5

Activated Partial Thromboplastin Time (APTT)

Question 6

Measures VII, III

Answer 6

PT

Question 7

Choice of test for monitoring warfarin therapy or oral anticoagulants

a. PT
b. APTT

Answer 7

a

Question 8

Depressed clotting factors? (Affected by Warfarin?

Answer 8

II, VII, IX, X

Question 9

In depressed clotting factor, whic among is not measured by PT?

Answer 9

Factor IX

Question 10

First factor to be affected by Warfarin?

Answer 10

VII

Question 11

Specimen for both PT and APTT?

Answer 11

50 or 100 uL PPP

Question 12

Aliquot is inubated at 37 C between 3 - 10mins

T or F

Answer 12

T

Question 13

Reagent for PT?

Answer 13

100 - 200 uL of Thromboplastin

Question 14

Reference: 12.6 to 14.6

a. PT
b. APTT

Answer 14

a

Question 15

Ref: 26-38

a. PT
b. APTT

Answer 15

b

Question 16

In International Normalized Ratio: What is the formula for PT?

Answer 16

( Patient’s PT / PT control ) ISI

Question 17

Healthy individuals should have INR of: 0.8 to 1.1

If patient is taking warfarin to prevent blood clots, doctors will most likely choose to keep INR between 2.0 and 3.0

T or F

Answer 17

T

Question 18

higher INR = Higher chances of bleeding

T or F

Answer 18

T

Question 19

Also known as Clot Busters

Answer 19

Warfarin

Question 20

Measures: XII, II, HMWK, PK, IX, VIII

Answer 20

APTT

Question 21

Monitor the effects of unfractionated heparin (UFH); detects Lupus Ac and antifactor-VIII antibody

Answer 21

APTT

Question 22

Reagent for APTT?

Answer 22

50 or 100 uL of Partial Thromboplastin / Cephalin

0.025 M CaCl2

Question 23

PT w/ INR: Abnormal
APTT: Abnormal

Problem?
a. Intrinsic
b. Extrinsic
c. Common

Answer 23

c excluding XIII

Question 24

PT w/ INR: Abnormal
APTT: Normal

Problem?
a. Intrinsic
b. Extrinsic
c. Common

Answer 24

b

Question 25

PT w/ INR: Normal
APTT: Abnormal

Problem?
a. Intrinsic
b. Extrinsic
c. Common

Answer 25

a

Question 26

Measures Conversion of Fibrinogen to Fibrin?

Answer 26

Thrombin Time