4.1 Quantitative Defect in platelets Flashcards
Most common cause of cinically importane bleeding
Thrombocytopenia
Manifest as small-vessel bleeding:
Small pinpoint hemorrhagic spots (<3mm)
Petechiae
Purplish skin discoloration observed in mucocutaneous bleeding (3mm to cm)
Purpura
Leakage of blood into large aras of the skin; Irregular bluish patch (1cm)
Ecchymosis
Risk for clinical bleeding increases progressively as the platelet count decrease from __________
50,000 /uL
or
<50x10^9/L
Decrease Platelet production may associated with:
- Fanconi anemia
- May-Hegglin anomaly
- Wsikott-Aldrich syndrome
-Bernard-soulier syndrome
T or F
T
Decreased plt count may associated with
Thrombocytopenia with absent radius (TAR) syndrome
T or F
T
Increase platelet destruction may include:
- Idiopathic thrombocytopenic purpura
- Drug induced
- Neonatal alloimmune/autoimmune thrombocytopenia
- Post transfusion purpua
T or F
T
Non immune cause of increase platelet destuction are:
- Gestational thrombocytopenia, HDN
- TTP
- HUS
- DIC
T or F
T
ADAMTS13 cleaves vWP
T or F
T
Abnormal platelet distribution (Sequestration) is a condition associated with?
Splenomegaly
Abnormal platelet distribution may cause by lowering the body temp to less than 25 C
T or F
T
Abnormal platelet distribution may cause by massive whole blood transfusion
T or F
T