4.1 Quantitative Defect in platelets Flashcards

1
Q

Most common cause of cinically importane bleeding

A

Thrombocytopenia

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2
Q

Manifest as small-vessel bleeding:

Small pinpoint hemorrhagic spots (<3mm)

A

Petechiae

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3
Q

Purplish skin discoloration observed in mucocutaneous bleeding (3mm to cm)

A

Purpura

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4
Q

Leakage of blood into large aras of the skin; Irregular bluish patch (1cm)

A

Ecchymosis

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5
Q

Risk for clinical bleeding increases progressively as the platelet count decrease from __________

A

50,000 /uL

or

<50x10^9/L

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6
Q

Decrease Platelet production may associated with:

  • Fanconi anemia
  • May-Hegglin anomaly
  • Wsikott-Aldrich syndrome
    -Bernard-soulier syndrome

T or F

A

T

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7
Q

Decreased plt count may associated with

Thrombocytopenia with absent radius (TAR) syndrome

T or F

A

T

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8
Q

Increase platelet destruction may include:

  • Idiopathic thrombocytopenic purpura
  • Drug induced
  • Neonatal alloimmune/autoimmune thrombocytopenia
  • Post transfusion purpua

T or F

A

T

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9
Q

Non immune cause of increase platelet destuction are:

  • Gestational thrombocytopenia, HDN
  • TTP
  • HUS
  • DIC

T or F

A

T

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10
Q

ADAMTS13 cleaves vWP

T or F

A

T

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11
Q

Abnormal platelet distribution (Sequestration) is a condition associated with?

A

Splenomegaly

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12
Q

Abnormal platelet distribution may cause by lowering the body temp to less than 25 C

T or F

A

T

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13
Q

Abnormal platelet distribution may cause by massive whole blood transfusion

T or F

A

T

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