3.2 Qualitative Platelet Disorders (Vascular disorder) Flashcards
Hereditary vascular disorder includes:
- Allergic purpura
- Paraproteinemia and Amyloidosis
- Senile purpua
- Drug-induced vasculitis
- Vitamine C deficiency
T or F
F
Acquired
Also known as Hereditary Hemorrhagic telangectasia
a. Rendu-Osler-Weber syndrome
b. Kasabac-Merritt Syndrome
c. Ehlers-Danlos Syndrome
d. Pseudoxanthoma elasticum
a
Also known as Hemangioma Thrombocytopenia syndrome
a. Rendu-Osler-Weber syndrome
b. Kasabac-Merritt Syndrome
c. Ehlers-Danlos Syndrome
d. Pseudoxanthoma elasticum
b
Presense of giant cavernous vasuclar tumor, thrombocytopenia and bleeding diathesis
a. Rendu-Osler-Weber syndrome
b. Kasabac-Merritt Syndrome
c. Ehlers-Danlos Syndrome
d. Pseudoxanthoma elasticum
b
Characterized by thin-walled blood vessels with a discontinuous endothelium
a. Rendu-Osler-Weber syndrome
b. Kasabac-Merritt Syndrome
c. Ehlers-Danlos Syndrome
d. Pseudoxanthoma elasticum
a
Also known as hypermobility syndrome
a. Rendu-Osler-Weber syndrome
b. Kasabac-Merritt Syndrome
c. Ehlers-Danlos Syndrome
d. Pseudoxanthoma elasticum
c
Disorder is due to defects in collagen production, structure or cross linking with resulting inadequacy of the connective tissues
a. Rendu-Osler-Weber syndrome
b. Kasabac-Merritt Syndrome
c. Ehlers-Danlos Syndrome
d. Pseudoxanthoma elasticum
c
A progressive disorder that is characterized by the accumulation of deposits of calcium and other minerals in elastiv fiber
a. Rendu-Osler-Weber syndrome
b. Kasabac-Merritt Syndrome
c. Ehlers-Danlos Syndrome
d. Pseudoxanthoma elasticum
d
Caused by defect in the gene that encodes the structure of fibrillin and elastic fivers, a major component of connective tissue
a. Marfan syndrome
b. Osteogenesis imperfecta
a
Hereditary connective tissue disease often due to mutations in genes coding for type 1 collagen
a. Marfan syndrome
b. Osteogenesis imperfecta
b
Nonthrombocytopenic purpuras characterized by allergic manifestations
a. Allergic purpura
b. Paraproteinemia and Amylodosis
c. Senile purpura
d. Drug-induced vasculitis
e. Vitamin C deficiency (Scurvy)
f. Henoch-Schonlein purpura
a
An Acute IgA-Mediated disorder with widespread generalized vasculitis involving the skin, joints, kidneys, gastrointestinal tract and, less commonly, the lungs
a. Allergic purpura
b. Paraproteinemia and Amylodosis
c. Senile purpura
d. Drug-induced vasculitis
e. Vitamin C deficiency (Scurvy)
f. Henoch-Schonlein purpura
f
in Allergic purpura, the Vasculitis is mediated by immune complexes containing Ig_ antibodies
A
High concentrations of this can cause severe hemorrhagic manifestations as a result of a combination of hyper viscosity and platelet dysfunction
a. Allergic purpura
b. Paraproteinemia and Amylodosis
c. Senile purpura
d. Drug-induced vasculitis
e. Vitamin C deficiency (Scurvy)
f. Henoch-Schonlein purpura
Paraprotein
It is the deposition of abnormal quantities of amyloid protein in tissues and may result to thrombosis and hemorrhage
Amyloidosis