6.1 Secondary hemosasis Flashcards
Secondary hemostasis is a process of forming a?
Fibrin clot
Coagulation factors can be:
- A enzyme precursors which is a substrate with no biologic activity until converted into active forms
Zymogems
This inreases the rate of further transformation of zymogems
Active serine proteases
Factors that are considered zymogens?
Factor:
II
VII
X
XI
XII
Prekalikrein
Coagulation factors can be:
- This requires to activate zymogens
Non-enzymic cofactors
Examples of non-enzymic cofactors?
Factor:
Tissue factor
V
VIII
High molecular Weight kininogen (HMWK)
This is the primary substrate of thrombin which is polymerized to form fibrin
Factor I
Fibrinogen
Also called factor IV
Calcium (Ca2+)
Phospholipid are provided by the platelets
T or F
T
Active form of Zymogens
Serine protease