1.2 Blood Vessels in Hemostasis Flashcards
Layers of Blood vessels:
Endothelial cell lining
- Innermost layer
Tunica intima
Layers of Blood vessels:
Contains the basement membrane (Collagen)
Tunica media
Layers of Blood vessels:
Connective tissue (Collagen, fibroblast)
- Outermost layer
Tunica adventitia
Functions of Blood vessels:
Promotes coagulation:
- Smooth muscle cells contract, the vascular lumen narrows, minimizes blood flow to injured site
Vasoconstriction
Functions of Blood vessels:
Promotes coagulation:
- flexible and Structural protein; binds and activates platelets important in platelet ADH
Collagen
Functions of Blood vessels:
Promotes coagulation:
- Large multimeric glycoprotein secreted by ECs and has a significant role in platelet ADH
von Willebrand’s Factor
Functions of Blood vessels:
Promotes coagulation:
- Secreted by damaged ECs in subendothelium and activates the coagulation system
Tissue factor
Functions of Blood vessels:
Inhibits coagulation:
- Provides a smooth inner surface of BV that promotes even blood flow, prevents PLT activation
Rhomboid cells of endothelium
Functions of Blood vessels:
Inhibits coagulation:
- Secreted by ECs; functions as platelet inhibitor and vasodilator; prevents activation of platelets
Prostacyclin
Functions of Blood vessels:
Inhibits coagulation:
- Secreted by ECs; induces smooth muscle relaxation and vasodilation
Nitric oxide
Functions of Blood vessels:
Inhibits coagulation:
- Regulates activation of extrinsic pathway coagulation
Tissue factor pathway inhibitor
Functions of Blood vessels:
Inhibits coagulation:
- Glycosaminoglycan that enhances the activity of antithrombin, a serine protease inhibitor
Heparan sulfate
Functions of Blood vessels:
Inhibits coagulation:
- Catalyzes the activation of the protein C pathway, which inhibits clotting factors 5a and 8a
Thrombomodulin
Functions of Blood vessels:
Inhibits coagulation:
- activates fibrinolysis
Tissue plasminogen factor
