6.4 Process of Fibrin Clot Formation Flashcards
The purpose of clot formation is to generate thrombin enzyme and produce?
Fibrin
Pathway weherin all the components of the system are found in the circulating blood
Intrinsic coag pathway
Intrinsic coag pathway may occur:
In vivo: Through exposed collagen
In Vitro: Through negatively charged Surfaces such as glass celite and koalin
Which begins the so-called contact phase
T or F
T
Extrinsic coag pathway consist only of?
Factor III
Factor IV
Factor VII
Extrinsic coag pathway:
This factor has a lipoprotein that released from cell membrane when there is vascular endothelial injury
Factor III
Extrinsic coag pathway:
A vitamin K-dependent facto
Factor VII
Factor VII can become active in the presence of?
Tissue factor and calcium
This pathway begins upon activation of factor X
Common coag pathway
After activation of Factor X, Forms a multimolecular complex know as?
Prothrombinase complexs
What are the factors needed from extrinsic to activate Factor X?
(IIIa)-> VIIa + Calcium
What are the factors needed from Intrinsic to activate Factor X?
(VIIIa)-> IXa + Calcium
what is the prothrombinase complex?
(Va)-> Xa + Calcium + Platelet plug
With the Help of Cofactor Va, Xa will convert ?
Prothrombin (II) to Thrombin (IIa)
Thrombin (IIa) will convert ______________ to soluble Fibrin
Fibrinogen (I)
Thrombin (IIa) Can convert V to Va
T or F
T
